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Ras Associated And Pleckstrin Homology Domains Containing Protein 1 (RAPH1)

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ALS2CR18; ALS2CR9; LPD; PREL2; RMO1; RalGDS/AF-6; Lamellipodin; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein; Proline-rich EVH1 ligand 2

Ras Associated And Pleckstrin Homology Domains Containing Protein 1 (RAPH1)
CCC M102
HGNC 14436
MGI 1924550
PubMed 18076380
RGD 1308387
UniProt Q70E73
Wiki RAPH1
The deduced 1,236-amino acid protein shares significant similarity with mouse Grb10. RT-PCR ELISA detected moderate to high RAPH1 expression in all adult and fetal tissues and specific brain regions examined, except lung. Highest expression was in brain. The PH domain of LPD specifically bound phosphatidylinositol 3,4-bisphosphate, which targeted the PH domain of LPD to ruffles in PDGF-treated rat fibroblasts. LPD overexpression increased lamellipodial protrusion velocity, an effect observed when VASP-related proteins are overexpressed or artificially targeted to the plasma membrane. Conversely, knockdown of mouse Lpd expression impaired lamellipodia formation in mouse melanoma cells, reduced velocity of residual lamellipodial protrusion, and decreased F-actin content.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Associated And Pleckstrin Homology Domains Containing Protein 1 (RAPH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Associated And Pleckstrin Homology Domains Containing Protein 1 (RAPH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Associated And Pleckstrin Homology Domains Containing Protein 1 (RAPH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Associated And Pleckstrin Homology Domains Containing Protein 1 (RAPH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Associated And Pleckstrin Homology Domains Containing Protein 1 (RAPH1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Associated And Pleckstrin Homology Domains Containing Protein 1 (RAPH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Associated And Pleckstrin Homology Domains Containing Protein 1 (RAPH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Associated And Pleckstrin Homology Domains Containing Protein 1 (RAPH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Associated And Pleckstrin Homology Domains Containing Protein 1 (RAPH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Associated And Pleckstrin Homology Domains Containing Protein 1 (RAPH1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Associated And Pleckstrin Homology Domains Containing Protein 1 (RAPH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Associated And Pleckstrin Homology Domains Containing Protein 1 (RAPH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Associated And Pleckstrin Homology Domains Containing Protein 1 (RAPH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Associated And Pleckstrin Homology Domains Containing Protein 1 (RAPH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Associated And Pleckstrin Homology Domains Containing Protein 1 (RAPH1) ELISA Kit Customized Service Offer
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  9. "c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis."Curr. Biol. 20:783-791(2010) [PubMed] [Europe PMC] [Abstract]
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  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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