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Regulator Of Chromosome Condensation 1 (RCC1)

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CHC1; Chromosome Condensation 1; Cell cycle regulatory protein

Regulator Of Chromosome Condensation 1 (RCC1)
CCC M114
HGNC 1913
MGI 1913989
PubMed 18442486
UniProt P18754
Wiki RCC1
RCC1 was found to have 14 exons, 8 of which (starting from the seventh one) coded the 7 repeated sequences of RCC1 protein. A single exon corresponded roughly to each repeat of the RCC1 protein except for the middle one, indicating that the RCC1 gene was generated through amplification of a primordial exon. Primer extension analysis demonstrated the presence of an internal promoter.the nucleotide exchange activity of RCC1, the only known nucleotide exchange factor for RAN, was required for microtubule aster formation with or without demembranated sperm in Xenopus egg extracts arrested in meiosis II. In the RCC1-depleted egg extracts, RanGTP, but not RanGDP, induced self-organization of microtubule asters, and the process required the activity of dynein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulator Of Chromosome Condensation 1 (RCC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulator Of Chromosome Condensation 1 (RCC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulator Of Chromosome Condensation 1 (RCC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulator Of Chromosome Condensation 1 (RCC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulator Of Chromosome Condensation 1 (RCC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulator Of Chromosome Condensation 1 (RCC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulator Of Chromosome Condensation 1 (RCC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulator Of Chromosome Condensation 1 (RCC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulator Of Chromosome Condensation 1 (RCC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulator Of Chromosome Condensation 1 (RCC1) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation."Genes Dev. 1:585-593(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Complete nucleotide sequence of the human RCC1 gene involved in coupling between DNA replication and mitosis."Genomics 11:459-461(1991) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Mammalian cells have two functional RCC1 proteins produced by alternative splicing."J. Cell Sci. 107:2203-2208(1994) [PubMed] [Europe PMC] [Abstract]
  5. "A 47-kDa human nuclear protein recognized by antikinetochore autoimmune sera is homologous with the protein encoded by RCC1, a gene implicated in onset of chromosome condensation."Proc. Natl. Acad. Sci. U.S.A. 87:8617-8621(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1."Nature 354:80-82(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Novel function of beta-arrestin2 in the nucleus of mature spermatozoa."J. Cell Sci. 119:3047-3056(2006) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis."Nat. Cell Biol. 9:596-603(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1."J. Cell Biol. 182:827-836(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein."Nature 466:1125-1128(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "The 1.7-A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller."Nature 392:97-101(1998) [PubMed] [Europe PMC] [Abstract]
  18. "Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)."Cell 105:245-255(2001) [PubMed] [Europe PMC] [Abstract]