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Regulator Of Chromosome Condensation 2 (RCC2)

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TD-60; RCC1-like protein TD-60; Telophase disk protein of 60 kDa

Regulator Of Chromosome Condensation 2 (RCC2)
CCC M115
HGNC 30297
MGI 1919784
PubMed 19738201
RGD 1309986
UniProt Q9P258
Wiki RCC2
RCC2 preferentially bound the nucleotide-free form of RAC1. the absence of RCC2 in HeLa cells substantially suppressed overall spindle assembly, blocked cells in prometaphase, and activated the spindle assembly checkpoint.TD60 is critical to localize both the chromosome passenger complex (CPC) and haspin kinase activity to centromeres and thus regulates Aurora B at several levels.
The deduced 522-amino acid protein contains an N-terminal nuclear localization signal, followed by 2 RCC1-2 motifs and 7 tandem RCC1-like repeats, each of which contains a hinge, an external sequence, and an RCC1-2 motif. Immunolocalization detected RCC2 at the inner centromere region in early mitotic HeLa cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulator Of Chromosome Condensation 2 (RCC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulator Of Chromosome Condensation 2 (RCC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulator Of Chromosome Condensation 2 (RCC2) Polyclonal Antibody Customized Service Offer
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n/a ELISA Kit for Regulator Of Chromosome Condensation 2 (RCC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulator Of Chromosome Condensation 2 (RCC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulator Of Chromosome Condensation 2 (RCC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulator Of Chromosome Condensation 2 (RCC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulator Of Chromosome Condensation 2 (RCC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulator Of Chromosome Condensation 2 (RCC2) ELISA Kit Customized Service Offer
  1. "The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression."Dev. Cell 5:295-307(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis."J. Cell Sci. 99:523-534(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Delay of HeLa cell cleavage into interphase using dihydrocytochalasin B: retention of a postmitotic spindle and telophase disc correlates with synchronous cleavage recovery."J. Cell Biol. 131:191-205(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Colocalization of TD-60 and INCENP throughout G2 and mitosis: evidence for their possible interaction in signalling cytokinesis."Chromosoma 107:461-470(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]