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Ras Homolog Enriched In Brain (RHEB)

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RHEB2; GTP-binding protein Rheb

Ras Homolog Enriched In Brain (RHEB)
CCC M142
HGNC 10011
MGI 97912
PubMed 23602449
RGD 621840
UniProt Q15382
Wiki Rheb
Rheb is a recently discovered member of the Ras superfamily that may be involved in neural plasticity. This function is novel and not typically associated with the Ras proteins.
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin / TOR / S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Homolog Enriched In Brain (RHEB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Homolog Enriched In Brain (RHEB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Homolog Enriched In Brain (RHEB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Homolog Enriched In Brain (RHEB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Homolog Enriched In Brain (RHEB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Homolog Enriched In Brain (RHEB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Homolog Enriched In Brain (RHEB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Homolog Enriched In Brain (RHEB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Homolog Enriched In Brain (RHEB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Homolog Enriched In Brain (RHEB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Homolog Enriched In Brain (RHEB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Homolog Enriched In Brain (RHEB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Homolog Enriched In Brain (RHEB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Homolog Enriched In Brain (RHEB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Homolog Enriched In Brain (RHEB) ELISA Kit Customized Service Offer
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  2. "Isolation of cDNA and genomic clones of a human Ras-related GTP-binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36."Genomics 34:114-118(1996) [PubMed] [Europe PMC] [Abstract]
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  7. "Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling."Genes Dev. 17:1829-1834(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity."Mol. Cell. Biol. 24:7965-7975(2004) [PubMed] [Europe PMC] [Abstract]
  9. "A tagging-via-substrate technology for detection and proteomics of farnesylated proteins."Proc. Natl. Acad. Sci. U.S.A. 101:12479-12484(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Rheb binds and regulates the mTOR kinase."Curr. Biol. 15:702-713(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1."FEBS Lett. 579:4763-4768(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids."Cell 141:290-303(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Structural basis for the unique biological function of small GTPase RHEB."J. Biol. Chem. 280:17093-17100(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo."Nat. Chem. Biol. 7:942-949(2011) [PubMed] [Europe PMC] [Abstract]
  16. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]