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Resistance To Inhibitors Of Cholinesterase 3 Homolog (RIC3)

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Resistance To Inhibitors Of Cholinesterase 3 Homolog (RIC3)
CCC M146
HGNC 30338
MGI 2443887
PubMed 18956371
UniProt Q7Z5B4
Wiki RIC3
RIC3 is a protein associated with nicotinic acetylcholine receptors (nAChRs), neurotransmitter-gated ion channels expressed at the neuromuscular junction and within the central and peripheral nervous systems, that can enhance functional expression of multiple nAChR subtypes.
The protein contains 2 N-terminal transmembrane domains separated by a proline-rich region; these are followed by a central coiled-coil domain and a long C-terminal domain. Northern blot analysis detected a 2.9-kb transcript in the excitable tissues muscle, brain, and heart, and additional transcripts in nonexcitable tissues. EST and mRNA database analysis revealed several splice variants, one of which encodes a truncated protein containing only the 2 transmembrane domains.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
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Antibodies n/a Monoclonal Antibody to Resistance To Inhibitors Of Cholinesterase 3 Homolog (RIC3) Monoclonal Antibody Customized Service Offer
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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Resistance To Inhibitors Of Cholinesterase 3 Homolog (RIC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Resistance To Inhibitors Of Cholinesterase 3 Homolog (RIC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Resistance To Inhibitors Of Cholinesterase 3 Homolog (RIC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Resistance To Inhibitors Of Cholinesterase 3 Homolog (RIC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Resistance To Inhibitors Of Cholinesterase 3 Homolog (RIC3) ELISA Kit Customized Service Offer
  1. "Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression."J. Biol. Chem. 278:34411-34417(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of a novel human variant of RIC-3, a putative chaperone of nicotinic acetylcholine receptors."Biosci. Rep. 28:299-306(2008) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells."J. Biol. Chem. 280:1257-1263(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3."J. Biol. Chem. 280:22502-22507(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors."J. Biol. Chem. 280:27062-27068(2005) [PubMed] [Europe PMC] [Abstract]
  11. "RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells."Mol. Pharmacol. 68:1431-1438(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Differential subcellular localization of RIC-3 isoforms and their role in determining 5-HT3 receptor composition."J. Biol. Chem. 282:26158-26166(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Lack of RIC-3 congruence with beta2 subunit-containing nicotinic acetylcholine receptors in bipolar disorder."Neuroscience 148:454-460(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  16. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]