≡

Synembryn (SYN)

[Edit]

RIC8A; RIC8; Synembryn A; Resistance To Inhibitors Of Cholinesterase 8 Homolog A

Synembryn (SYN)
CCC M147
HGNC 29550
MGI 2141866
PubMed 10985349
RGD 727957
UniProt Q9NPQ8
Wiki RIC8A
Ric8a, a homolog of C. elegans Ric8/synembryn. Database analysis identified 3 splice variants of human RIC8A that encode deduced proteins of 531, 537, and 401 amino acids. The 531-amino acid RIC8A isoform shares 87% identity with rat Ric8a. The 537-amino acid protein is identical to the 531-amino acid protein except for a 6-amino acid insertion, including a polyproline sequence, at codon 355.
The variant encoding the 401-amino acid protein is derived from a 1-bp insertion at codon 395 of the transcript encoding the 531-amino acid protein. The resultant frameshift leads to a protein with 5 different C-terminal amino acids and a new stop codon that forms a consensus CAAX box for geranylgeranyl modification.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synembryn (SYN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synembryn (SYN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synembryn (SYN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synembryn (SYN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synembryn (SYN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synembryn (SYN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synembryn (SYN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synembryn (SYN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synembryn (SYN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synembryn (SYN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synembryn (SYN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synembryn (SYN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synembryn (SYN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synembryn (SYN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synembryn (SYN) ELISA Kit Customized Service Offer
  1. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells."Genes Cells 11:487-498(2006) [PubMed] [Europe PMC] [Abstract]
  8. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]