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RecQ Mediated Genome Instability Protein 1 (RMI1)

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BLAP75; FAAP75; C9orf76; BLM-Associated Polypeptide,75 kDa

RecQ Mediated Genome Instability Protein 1 (RMI1)
CCC M152
HGNC 25764
MGI 1921636
PubMed 21199368
RGD 1310671
UniProt Q9H9A7
Wiki RMI1
RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday junctions.deduced 625-amino acid protein contains an N-terminal nucleic acid binding domain and a C-terminal domain conserved across several eukaryotic species.BLAP75 was associated with all 3 BLM-containing protein complexes immunopurified from HeLa cells. BLAP75 colocalized with BLM in subnuclear foci in response to DNA damage, and its depletion by small interfering RNA (siRNA) impaired the recruitment of BLM to these foci. Depletion of BLAP75 also resulted in deficient BLM phosphorylation during mitosis as well as defective cell proliferation. Cells depleted of BLAP75 displayed an increased level of sister-chromatid exchange, similar to cells depleted of BLM.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RecQ Mediated Genome Instability Protein 1 (RMI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RecQ Mediated Genome Instability Protein 1 (RMI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RecQ Mediated Genome Instability Protein 1 (RMI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RecQ Mediated Genome Instability Protein 1 (RMI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RecQ Mediated Genome Instability Protein 1 (RMI1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RecQ Mediated Genome Instability Protein 1 (RMI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RecQ Mediated Genome Instability Protein 1 (RMI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RecQ Mediated Genome Instability Protein 1 (RMI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RecQ Mediated Genome Instability Protein 1 (RMI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RecQ Mediated Genome Instability Protein 1 (RMI1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RecQ Mediated Genome Instability Protein 1 (RMI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RecQ Mediated Genome Instability Protein 1 (RMI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RecQ Mediated Genome Instability Protein 1 (RMI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RecQ Mediated Genome Instability Protein 1 (RMI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RecQ Mediated Genome Instability Protein 1 (RMI1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity."EMBO J. 24:1465-1476(2005) [PubMed] [Europe PMC] [Abstract]
  5. "A double Holliday junction dissolvasome comprising BLM, topoisomerase III alpha, and BLAP75."J. Biol. Chem. 281:13861-13864(2006) [PubMed] [Europe PMC] [Abstract]
  6. "BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates."Proc. Natl. Acad. Sci. U.S.A. 103:4068-4073(2006) [PubMed] [Europe PMC] [Abstract]
  7. "RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability."Genes Dev. 22:2843-2855(2008) [PubMed] [Europe PMC] [Abstract]
  8. "BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome."Genes Dev. 22:2856-2868(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair."Proc. Natl. Acad. Sci. U.S.A. 110:10646-10651(2013) [PubMed] [Europe PMC] [Abstract]