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Ras Related GTP Binding Protein C (RRAGC)

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GTR2; RAGC; TIB929; GTPase-interacting protein 2

Ras Related GTP Binding Protein C (RRAGC)
CCC M164
HGNC 19902
MGI 1858751
PubMed 11073942
RGD 1311760
UniProt Q9HB90
Wiki RRAGC
RRAGC is a monomeric guanine nucleotide-binding protein, or G protein. The deduced 399-amino acid protein contains 3 phosphate/magnesium-binding motifs, 3 guanine nucleotide-binding motifs, and a C-terminal leucine zipper and coiled-coil structure. RRAGC and RRAGD share 81% amino acid homology, including 90% identity in their central portions; the N and C termini are less conserved.
RRAGC interacted with both the GDP- and GTP-bound conformations of RRAGA. Deletion analysis showed that the C-terminal regions of RRAGC and RRAGA mediated the interaction. The authors also showed that the subcellular localization of RRAGC was influenced by the nucleotide-bound state of RRAGA and its localization.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Related GTP Binding Protein C (RRAGC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Related GTP Binding Protein C (RRAGC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Related GTP Binding Protein C (RRAGC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Related GTP Binding Protein C (RRAGC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Related GTP Binding Protein C (RRAGC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Related GTP Binding Protein C (RRAGC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Related GTP Binding Protein C (RRAGC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Related GTP Binding Protein C (RRAGC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Related GTP Binding Protein C (RRAGC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Related GTP Binding Protein C (RRAGC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Related GTP Binding Protein C (RRAGC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Related GTP Binding Protein C (RRAGC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Related GTP Binding Protein C (RRAGC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Related GTP Binding Protein C (RRAGC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Related GTP Binding Protein C (RRAGC) ELISA Kit Customized Service Offer
  1. "Adenovirus immunoregulatory genes and their cellular targets."Virology 279:1-8(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B."J. Biol. Chem. 276:7246-7257(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract].
  6. "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D."J. Biol. Chem. 279:8343-8350(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1."Science 320:1496-1501(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids."Cell 141:290-303(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling."Mol. Cell 46:833-846(2012) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1."Nature 519:477-481(2015) [PubMed] [Europe PMC] [Abstract]
  13. "Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1."Science 347:188-194(2015) [PubMed] [Europe PMC] [Abstract]