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R-Spondin 3 (RSPO3)

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CRISTIN1; PWTSR; THSD2; Thrombospondin,Type I,Domain Containing 2; Protein with TSP type-1 repeat; Roof plate-specific spondin-3

R-Spondin 3 (RSPO3)
CCC M173
HGNC 20866
MGI 1920030
PubMed 22895193
RGD 1563246
UniProt Q9BXY4
Wiki RSPO3
RSPO3 encodes a member of the thrombospondin type 1 repeat supergene family. In addition, the protein contains a furin-like cysteine-rich region. Furin-like repeat domains have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases.The 272-amino acid protein has an N-terminal cys-rich domain (CRD) and a central thrombospondin type-1 (THBS1) repeat (TSR) domain. Northern blot analysis detected 3.0- and 4.0-kb transcripts in placenta, lung, and skeletal muscle. RT-PCR revealed ubiquitous expression, with highest levels in placenta, small intestine, fetal thymus, and lymph node. RSPO3 expression was detected in all tumor tissues examined except a lung carcinoma and an ovarian carcinoma.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM173Hu01 Recombinant R-Spondin 3 (RSPO3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM173Hu01 Polyclonal Antibody to R-Spondin 3 (RSPO3) WB; IHC; ICC; IP.
MAM173Hu21 Monoclonal Antibody to R-Spondin 3 (RSPO3) WB; IHC; ICC; IP.
Assay Kits SEM173Hu ELISA Kit for R-Spondin 3 (RSPO3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant R-Spondin 3 (RSPO3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to R-Spondin 3 (RSPO3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to R-Spondin 3 (RSPO3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for R-Spondin 3 (RSPO3) CLIA Kit Customized Service Offer
n/a ELISA Kit for R-Spondin 3 (RSPO3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant R-Spondin 3 (RSPO3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to R-Spondin 3 (RSPO3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to R-Spondin 3 (RSPO3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for R-Spondin 3 (RSPO3) CLIA Kit Customized Service Offer
n/a ELISA Kit for R-Spondin 3 (RSPO3) ELISA Kit Customized Service Offer
  1. "Cloning and identification of a cDNA that encodes a novel human protein with thrombospondin type I repeat domain, hPWTSR."Mol. Biol. Rep. 29:287-292(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "R-spondin proteins: a novel link to beta-catenin activation."Cell Cycle 5:23-26(2006) [PubMed] [Europe PMC] [Abstract]
  6. "LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling."EMBO Rep. 12:1055-1061(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling."Nature 476:293-297(2011) [PubMed] [Europe PMC] [Abstract]
  8. "LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor."PLoS ONE 7:E37137-E37137(2012) [PubMed] [Europe PMC] [Abstract]