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RuvB Like Protein 2 (RUVBL2)

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CGI-46; ECP51; RVB2; TIP48; TIP49B; TIH2; INO80J; Reptin 52; INO80 Complex Subunit J; 48 kDa TATA box-binding protein-interacting protein; 51 kDa erythrocyte cytosolic protein

RuvB Like Protein 2 (RUVBL2)
CCC M175
HGNC 10475
MGI 1342299
PubMed 20371770
RGD 1306509
UniProt Q9Y230
Wiki RUVBL2
RUVBL2 encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. However, the evidence for whether RUVBL2 has DNA helicase activity is contradictory. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.
The deduced 463-amino acid protein contains Walker A and B motifs and is highly similar structurally to other TIP49 family proteins, including TIP49A (RUVBL1). Western blot analysis revealed that, similar to RUVBL1, RUVBL2 is ubiquitously expressed, with highest levels in testis and thymus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RuvB Like Protein 2 (RUVBL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RuvB Like Protein 2 (RUVBL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RuvB Like Protein 2 (RUVBL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RuvB Like Protein 2 (RUVBL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for RuvB Like Protein 2 (RUVBL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RuvB Like Protein 2 (RUVBL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RuvB Like Protein 2 (RUVBL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RuvB Like Protein 2 (RUVBL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RuvB Like Protein 2 (RUVBL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for RuvB Like Protein 2 (RUVBL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RuvB Like Protein 2 (RUVBL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RuvB Like Protein 2 (RUVBL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RuvB Like Protein 2 (RUVBL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RuvB Like Protein 2 (RUVBL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for RuvB Like Protein 2 (RUVBL2) ELISA Kit Customized Service Offer
  1. "Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins."Biochim. Biophys. Acta 1446:365-370(1999) [PubMed] [Europe PMC] [Abstract]
  2. "TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a."J. Biol. Chem. 274:22437-22444(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Human TIP49b/RUVBL2 gene: genomic structure, expression pattern, physical link to the human CGB/LHB gene cluster on chromosome 19q13.3."Ann. Genet. 43:69-74(2000) [PubMed] [Europe PMC] [Abstract]
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  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]