≡

RuvB Like Protein 1 (RUVBL1)

[Edit]

ECP54; RVB1; TIP49; TIP49A; TIH1; Rvb1; INO80H; Pontin; INO80 Complex Subunit H; 49 kDa TATA box-binding protein-interacting protein; 54 kDa erythrocyte cytosolic protein

RuvB Like Protein 1 (RUVBL1)
CCC M176
HGNC 10474
MGI 1928760
PubMed 21617703
RGD 68373
UniProt Q9Y265
Wiki RUVBL1
RUVBL1 coimmunoprecipitated with several cellular proteins and was present in the RNA polymerase II holoenzyme complex purified over multiple chromatographic steps.
The calculated molecular mass and pI of the predicted 456-amino acid protein were close to the experimentally determined values of 54 kD and 6.5. By immunofluorescence, Holzmann et al. (1998) determined that NMP238 is found primarily in the nucleus, although it is also present in the cytoplasm. The NMP238 staining pattern appeared as punctate signals in both in situ prepared nuclear matrices and in the nucleoplasm of whole cells. Northern blot and RNA dot blot analysis revealed that NMP238 is expressed ubiquitously as an approximately 1.8-kb mRNA.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RuvB Like Protein 1 (RUVBL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RuvB Like Protein 1 (RUVBL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RuvB Like Protein 1 (RUVBL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RuvB Like Protein 1 (RUVBL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RuvB Like Protein 1 (RUVBL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RuvB Like Protein 1 (RUVBL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RuvB Like Protein 1 (RUVBL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RuvB Like Protein 1 (RUVBL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RuvB Like Protein 1 (RUVBL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RuvB Like Protein 1 (RUVBL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RuvB Like Protein 1 (RUVBL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RuvB Like Protein 1 (RUVBL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RuvB Like Protein 1 (RUVBL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RuvB Like Protein 1 (RUVBL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RuvB Like Protein 1 (RUVBL1) ELISA Kit Customized Service Offer
  1. "TIP49, homologous to the bacterial DNA helicase RuvB, acts as an autoantigen in human."Biochem. Biophys. Res. Commun. 245:819-823(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of the ubiquitously occurring nuclear matrix protein NMP 238."Biochem. Biophys. Res. Commun. 252:39-45(1998) [PubMed] [Europe PMC] [Abstract]
  3. "An eukaryotic RuvB-like protein (RUVBL1) essential for growth."J. Biol. Chem. 273:27786-27793(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein."Proc. Natl. Acad. Sci. U.S.A. 95:14787-14792(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins."Biochim. Biophys. Acta 1446:365-370(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Purification, cloning, and characterization of a profibrinolytic plasminogen-binding protein, TIP49a."J. Biol. Chem. 276:179-186(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. , Submitted (DEC-2008) to UniProtKB
  11. "An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc."Mol. Cell 5:321-330(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex."J. Biol. Chem. 278:42733-42736(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis."Cell 102:463-473(2000) [PubMed] [Europe PMC] [Abstract]
  14. "The ATP-dependent helicase RUVBL1/TIP49a associates with tubulin during mitosis."Cell Motil. Cytoskeleton 56:79-93(2003) [PubMed] [Europe PMC] [Abstract]
  15. "TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a."J. Biol. Chem. 274:22437-22444(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity."EMBO J. 19:6121-6130(2000) [PubMed] [Europe PMC] [Abstract]
  17. "BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation."Mol. Cell. Biol. 22:1307-1316(2002) [PubMed] [Europe PMC] [Abstract]
  18. "TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling."Cancer Res. 63:8726-8734(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans."Mol. Cell. Biol. 24:1884-1896(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."Cell 121:873-885(2005) [PubMed] [Europe PMC] [Abstract]
  21. "A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex."J. Biol. Chem. 280:41207-41212(2005) [PubMed] [Europe PMC] [Abstract]
  22. "The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription."J. Cell Sci. 118:3117-3129(2005) [PubMed] [Europe PMC] [Abstract]
  23. "Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex."J. Mol. Biol. 366:179-192(2007) [PubMed] [Europe PMC] [Abstract]
  24. "Functional characterization of the OFD1 protein reveals a nuclear localization and physical interaction with subunits of a chromatin remodeling complex."Mol. Biol. Cell 18:4397-4404(2007) [PubMed] [Europe PMC] [Abstract]
  25. "A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly."Mol. Cell. Biol. 27:6782-6793(2007) [PubMed] [Europe PMC] [Abstract]
  26. "A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair."Nat. Struct. Mol. Biol. 14:1165-1172(2007) [PubMed] [Europe PMC] [Abstract]
  27. "Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition."Mol. Cell. Biol. 28:435-447(2008) [PubMed] [Europe PMC] [Abstract]
  28. "Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery."Hum. Mol. Genet. 18:2115-2126(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  30. "CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability."Mol. Cell 39:839-850(2010) [PubMed] [Europe PMC] [Abstract]
  31. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  32. "Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling."J. Biol. Chem. 286:11283-11289(2011) [PubMed] [Europe PMC] [Abstract]
  33. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  34. "USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing."Genes Dev. 27:1581-1595(2013) [PubMed] [Europe PMC] [Abstract]
  35. "ANP32E is a histone chaperone that removes H2A.Z from chromatin."Nature 505:648-653(2014) [PubMed] [Europe PMC] [Abstract]
  36. "Crystal structure of the human AAA+ protein RuvBL1."J. Biol. Chem. 281:38918-38929(2006) [PubMed] [Europe PMC] [Abstract]