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Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 (SART1)

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Ara1; HOMS1; Snu66; SNRNP110; Small Nuclear Ribonucleoprotein 110kDa; U4/U6.U5 tri-snRNP-associated protein 1

Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 (SART1)
CCC M186
HGNC 10538
MGI 1309453
PubMed 9449708
RGD 61930
UniProt O43290
Wiki SART1
encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 (SART1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 (SART1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 (SART1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 (SART1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 (SART1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 (SART1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 (SART1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 (SART1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 (SART1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 (SART1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 (SART1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 (SART1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 (SART1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 (SART1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 (SART1) ELISA Kit Customized Service Offer
  1. "A gene encoding antigenic peptides of human squamous cell carcinoma recognized cytotoxic T lymphocytes."J. Exp. Med. 187:277-288(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The 65 and 110 kDa SR-related proteins of the U4/U6*U5 tri-snRNP are essential for the assembly of mature spliceosomes."EMBO J. 20:2553-2563(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Intron loss in the SART1 genes of Fugu rubripes and Tetraodon nigroviridis."Gene 271:43-49(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular characterization of an autoallergen, Hom s 1, identified by serum IgE from atopic dermatitis patients."J. Invest. Dermatol. 111:1178-1183(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP."RNA 12:1418-1430(2006) [PubMed] [Europe PMC] [Abstract]
  10. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]