Sentrin Specific Protease 6 (SENP6)

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SSP1; SUSP1; FKSG6; SUMO1/Sentrin Specific Peptidase 6; SUMO-1-specific protease 1; Sentrin/SUMO-specific protease SENP6

Sentrin Specific Protease 6 (SENP6)
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1), are structurally related to ubiquitin and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sentrin Specific Protease 6 (SENP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sentrin Specific Protease 6 (SENP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sentrin Specific Protease 6 (SENP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sentrin Specific Protease 6 (SENP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sentrin Specific Protease 6 (SENP6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sentrin Specific Protease 6 (SENP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sentrin Specific Protease 6 (SENP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sentrin Specific Protease 6 (SENP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sentrin Specific Protease 6 (SENP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sentrin Specific Protease 6 (SENP6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sentrin Specific Protease 6 (SENP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sentrin Specific Protease 6 (SENP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sentrin Specific Protease 6 (SENP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sentrin Specific Protease 6 (SENP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sentrin Specific Protease 6 (SENP6) ELISA Kit Customized Service Offer
  1. "Ubiquitin-like proteins: new wines in new bottles."Gene 248:1-14(2000) [PubMed] [Europe PMC] [Abstract]
  2. "A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs."J. Biol. Chem. 275:14102-14106(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1."J. Biol. Chem. 281:30669-30677(2006) [PubMed] [Europe PMC] [Abstract]
  8. "SUSP1 antagonizes formation of highly SUMO2/3-conjugated species."J. Cell Biol. 174:939-949(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7."J. Biol. Chem. 283:32045-32055(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response." Oncogene 27:931-941(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "The SUMO protease SENP6 is essential for inner kinetochore assembly."J. Cell Biol. 188:681-692(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Regulation of DNA repair through desumoylation and sumoylation of replication protein A complex."Mol. Cell 39:333-345(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "The SUMO protease SENP6 is a direct regulator of PML nuclear bodies."Mol. Biol. Cell 22:78-90(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]