Serine Incorporator 1 (SERINC1)

Serinc1 specifically enhances the incorporation of serine molecules into the membrane lipid, phosphatidylserine-to investigate the effect of serinc proteins on cellular serine, rat serinc1 in e. coli and mammalian cos cells, first monitoring their cellular and vesicular uptake of serine. serine uptake into serinc1-expressing e. coli cells was 102 ± 4% of the base rate of control cells, and serine uptake into serinc1-expressing cos cells was 99 ± 3% of the base rate of control cells. thus, the serine transport across these membranes was unaffected by serinc1, which supports the idea that serinc is not an amino acid transporter. although other e. coli lipids were faintly radiolabeled by way of other serine metabolic pathways, these activities were unaffected by serinc1, indicating the specific action on phosphatidylserine synthesis.