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Single Ig IL1 Related Receptor (SIGIRR)

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TIR8; Single Ig IL-1R-related molecule; Toll/interleukin-1 receptor 8; Single immunoglobulin domain-containing IL1R-related protein

Single Ig IL1 Related Receptor (SIGIRR)
CCC M229
HGNC 30575
MGI 1344402
PubMed 12925853
RGD 1306732
UniProt Q6IA17
Wiki SIGIRR
The deduced 410-amino acid human protein, which is 82% identical to the mouse sequence and 23% identical to IL1R, has no signal peptide and contains a short 118-amino acid single immunoglobulin (Ig) extracellular domain with 4 potential N-glycosylation sites; a transmembrane region; and a 268-amino acid cytoplasmic tail with 4 IL1R-like signaling motifs. However, 2 changes in the regions conserved with IL1R (ser447 in IL1R replaced by cys222 in motif 3 of SIGIRR, and tyr536 in IL1R replaced by leu305 in motif 4 of SIGIRR) are predicted to abrogate signaling capabilities. Northern blot analysis revealed wide but differential expression of predominant 2.4- and 1.5-kb transcripts and minor 4.4- and 0.9-kb transcripts in all tissues tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM229Hu01 Recombinant Single Ig IL1 Related Receptor (SIGIRR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM229Hu01 Polyclonal Antibody to Single Ig IL1 Related Receptor (SIGIRR) WB; IHC; ICC; IP.
LAM229Hu71 Biotin-Linked Polyclonal Antibody to Single Ig IL1 Related Receptor (SIGIRR) WB; IHC; ICC.
Assay Kits SEM229Hu ELISA Kit for Single Ig IL1 Related Receptor (SIGIRR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM229Mu01 Recombinant Single Ig IL1 Related Receptor (SIGIRR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM229Mu01 Polyclonal Antibody to Single Ig IL1 Related Receptor (SIGIRR) WB; IHC; ICC; IP.
Assay Kits SEM229Mu ELISA Kit for Single Ig IL1 Related Receptor (SIGIRR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM229Ra01 Recombinant Single Ig IL1 Related Receptor (SIGIRR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM229Ra01 Polyclonal Antibody to Single Ig IL1 Related Receptor (SIGIRR) WB; IHC; ICC; IP.
LAM229Ra71 Biotin-Linked Polyclonal Antibody to Single Ig IL1 Related Receptor (SIGIRR) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Single Ig IL1 Related Receptor (SIGIRR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Single Ig IL1 Related Receptor (SIGIRR) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  5. "Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily."Cytokine 11:389-399(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR."Eur. Cytokine Netw. 14:211-218(2003) [PubMed] [Europe PMC] [Abstract]
  7. "SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling."Nat. Immunol. 4:920-927(2003) [PubMed] [Europe PMC] [Abstract]
  8. "SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms."J. Biol. Chem. 280:25233-25241(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Down-regulation of single immunoglobulin interleukin-1R-related molecule (SIGIRR)/TIR8 expression in intestinal epithelial cells during inflammation."Clin. Exp. Immunol. 162:348-361(2010) [PubMed] [Europe PMC] [Abstract]
  10. "A novel binding protein of single immunoglobulin IL-1 receptor-related molecule: Paralemmin-3."Biochem. Biophys. Res. Commun. 404:1029-1033(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]