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SNF2 Related CREBBP Activator Protein (SRCAP)

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EAF1; SWR1; DOMO1; Swi2/Snf2-Related ATPase Homolog; Domino Homolog 1; Helicase SRCAP

SNF2 Related CREBBP Activator Protein (SRCAP)
CCC M283
HGNC 16974
MGI 2444036
PubMed 22479200
RGD 1565642
UniProt Q6ZRS2
Wiki SRCAP
SRCAP increased transcription of a reporter plasmid when it was cotransfected with the transcription activation domain of CBP. Endogenous SRCAP immunoprecipitated from nuclear extracts of a human lung epithelial cell line had ATPase activity, and the C-terminal half of SRCAP enhanced the ability of CBP to activate transcription. Adenovirus protein E1A blocked the ability of CBP to function as a coactivator for a number of transcription factors. The deduced 2,971-amino acid protein has a calculated molecular mass of 315 kD. It has a highly charged N-terminal domain, a central CBP-binding domain, a second charged domain, and a putative C-terminal DNA-binding domain. A complete ATPase domain, consisting of 7 highly conserved regions, are dispersed over the length of the protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SNF2 Related CREBBP Activator Protein (SRCAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SNF2 Related CREBBP Activator Protein (SRCAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SNF2 Related CREBBP Activator Protein (SRCAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SNF2 Related CREBBP Activator Protein (SRCAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for SNF2 Related CREBBP Activator Protein (SRCAP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SNF2 Related CREBBP Activator Protein (SRCAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SNF2 Related CREBBP Activator Protein (SRCAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SNF2 Related CREBBP Activator Protein (SRCAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SNF2 Related CREBBP Activator Protein (SRCAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for SNF2 Related CREBBP Activator Protein (SRCAP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SNF2 Related CREBBP Activator Protein (SRCAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SNF2 Related CREBBP Activator Protein (SRCAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SNF2 Related CREBBP Activator Protein (SRCAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SNF2 Related CREBBP Activator Protein (SRCAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for SNF2 Related CREBBP Activator Protein (SRCAP) ELISA Kit Customized Service Offer
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  5. "Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein."J. Biol. Chem. 274:16370-16376(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP."J. Biol. Chem. 275:7184-7188(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of cAMP-responsive element-binding protein-mediated transcription by the SNF2/SWI-related protein, SRCAP."J. Biol. Chem. 276:40721-40726(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription."J. Virol. 75:10033-10040(2001) [PubMed] [Europe PMC] [Abstract]
  9. "SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1."Mol. Endocrinol. 17:2519-2528(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans."Mol. Cell. Biol. 24:1884-1896(2004) [PubMed] [Europe PMC] [Abstract]
  11. "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes."J. Biol. Chem. 280:13665-13670(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway."Mol. Cell. Biol. 25:6559-6569(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes."Biochemistry 45:5671-5677(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  15. "The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters."J. Biol. Chem. 282:26132-26139(2007) [PubMed] [Europe PMC] [Abstract]
  16. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Mutations in SRCAP, encoding SNF2-related CREBBP activator protein, cause Floating-Harbor syndrome." Am. J. Hum. Genet. 90:308-313(2012) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]