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Steroid 5 Alpha Reductase 3 (SRD5a3)

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SRD5A2L; SRD5A2L1; 3-Oxo-5 Alpha-Steroid Delta 4-Dehydrogenase Alpha 3; Polyprenol reductase

Steroid 5 Alpha Reductase 3 (SRD5a3)
CCC M284
HGNC 25812
MGI 1930252
PubMed 20637498
RGD 1308828
UniProt Q9H8P0
SRD5A3 encodes a steroid 5-alpha-reductase that produces the androgen 5-alpha-dihydrotestosterone (DHT) from testosterone. Mutant SRD5A3 proteins with changes in regions known to affect other SRD5 proteins also abrogated SRD5A3 activity. Knockdown of SRD5A3 expression in an HRPC cell line by siRNA resulted in a significant decrease in DHT production and a marked reduction in cell viability.One gene identified by the screen was confirmed by RT-PCR and Northern blot analyses to be upregulated in HRPC cells but to have little, if any, expression in normal adult organs. The deduced 318-amino acid protein shares sequence similarity and a conserved C-terminal region with steroid 5-alpha-reductases SRD5A1 and SRD5A2, and was designated SRD5A3.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Steroid 5 Alpha Reductase 3 (SRD5a3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Steroid 5 Alpha Reductase 3 (SRD5a3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Steroid 5 Alpha Reductase 3 (SRD5a3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Steroid 5 Alpha Reductase 3 (SRD5a3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Steroid 5 Alpha Reductase 3 (SRD5a3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Steroid 5 Alpha Reductase 3 (SRD5a3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Steroid 5 Alpha Reductase 3 (SRD5a3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Steroid 5 Alpha Reductase 3 (SRD5a3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Steroid 5 Alpha Reductase 3 (SRD5a3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Steroid 5 Alpha Reductase 3 (SRD5a3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Steroid 5 Alpha Reductase 3 (SRD5a3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Steroid 5 Alpha Reductase 3 (SRD5a3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Steroid 5 Alpha Reductase 3 (SRD5a3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Steroid 5 Alpha Reductase 3 (SRD5a3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Steroid 5 Alpha Reductase 3 (SRD5a3) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer."Cancer Sci. 99:81-86(2008) [PubMed] [Europe PMC] [Abstract]
  5. "SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder." Cell 142:203-217(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Next generation sequencing in a family with autosomal recessive Kahrizi syndrome (OMIM 612713) reveals a homozygous frameshift mutation in SRD5A3."Eur. J. Hum. Genet. 19:115-117(2011) [PubMed] [Europe PMC] [Abstract]
  7. "SRD5A3-CDG: A patient with a novel mutation."Eur. J. Paediatr. Neurol. 16:554-556(2012) [PubMed] [Europe PMC] [Abstract]