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Source Of Immunodominant MHC Associated Peptides (SIMP)

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STT3B; STT3,Subunit Of The Oligosaccharyltransferase Complex,Homolog B; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

Source Of Immunodominant MHC Associated Peptides (SIMP)
CCC M319
HGNC 30611
MGI 1915542
PubMed 22607976
RGD 1311563
UniProt Q8TCJ2
Wiki STT3B
The SIMP protein contains a highly immunogenic minor histocompatibility antigen epitope of 9 amino acids, B6(dom1). Like ITM1, SIMP is homologous to yeast STT3, an oligosaccharyltransferase essential for cell proliferation .
The B6(dom1) antigen corresponds to amino acids 770 to 778 of the 823-amino acid Simp protein, and analysis of cytotoxic T-lymphocyte activity in different mouse strains confirmed the presence of a polymorphism at amino acid 776. The 826-amino acid human protein shares 97% identity with the mouse protein. Sequence analysis of SIMP cDNA from 14 individuals failed to reveal polymorphism of human SIMP.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Source Of Immunodominant MHC Associated Peptides (SIMP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Source Of Immunodominant MHC Associated Peptides (SIMP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Source Of Immunodominant MHC Associated Peptides (SIMP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Source Of Immunodominant MHC Associated Peptides (SIMP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Source Of Immunodominant MHC Associated Peptides (SIMP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Source Of Immunodominant MHC Associated Peptides (SIMP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Source Of Immunodominant MHC Associated Peptides (SIMP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Source Of Immunodominant MHC Associated Peptides (SIMP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Source Of Immunodominant MHC Associated Peptides (SIMP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Source Of Immunodominant MHC Associated Peptides (SIMP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Source Of Immunodominant MHC Associated Peptides (SIMP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Source Of Immunodominant MHC Associated Peptides (SIMP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Source Of Immunodominant MHC Associated Peptides (SIMP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Source Of Immunodominant MHC Associated Peptides (SIMP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Source Of Immunodominant MHC Associated Peptides (SIMP) ELISA Kit Customized Service Offer
  1. "The model B6dom1 minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene."Immunogenetics 54:562-569(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties."Mol. Cell 12:101-111(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits."Biochemistry 44:5982-5992(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms."Cell 136:272-283(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein."Mol. Cell 47:99-110(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Mutations in STT3A and STT3B cause two congenital disorders of glycosylation."Hum. Mol. Genet. 22:4638-4645(2013) [PubMed] [Europe PMC] [Abstract]