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Suppressor Of G2 Allele Of SKP1 (SUGT1)

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SGT1

Suppressor Of G2 Allele Of SKP1 (SUGT1)
CCC M323
HGNC 16987
MGI 1915205
PubMed 10445024
RGD 1307550
UniProt Q9Y2Z0
Wiki SUGT1
SUGT1 is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions.
The SGT1 protein physically associates with the SKP1 protein and the SCF (SKP1/Cdc53/F box protein) ubiquitin ligase complex and is required for kinetochore function, where it serves as an activator of the Ctf13 protein. Kitagawa et al. (1999) also cloned the human homolog of the yeast SGT1 gene. The yeast and human SGT1 proteins share 26% identity and 30% similarity. Human SGT1 could perform the essential functions of SGT1 in budding yeast, indicating that SGT1 function is conserved throughout eukaryotes.

Organism species: Homo sapiens (Human)

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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
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Organism species: Rattus norvegicus (Rat)

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  1. "SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex."Mol. Cell 4:21-33(1999) [PubMed] [Europe PMC] [Abstract]
  2. Thesis (2001), University of Goettingen, Germany
  3. "Identification of a novel splice variant: human SGT1B (SUGT1B)."DNA Seq. 14:436-441(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  7. , Submitted (JUL-2007) to UniProtKB
  8. "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins."J. Biol. Chem. 278:26923-26928(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Nuclear translocation of Sgt1 depends on its phosphorylation state."Int. J. Biochem. Cell Biol. 43:1747-1753(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain."J. Biol. Chem. 279:16511-16517(2004) [PubMed] [Europe PMC] [Abstract]