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Tar RNA Binding Protein 2 (TARBP2)

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TRBP; TRBP1; TRBP2; Trans-activation-responsive RNA-binding protein; RISC-loading complex subunit TARBP2

Tar RNA Binding Protein 2 (TARBP2)
CCC M339
HGNC 11569
MGI 103027
PubMed 22698405
RGD 1307375
UniProt Q15633
Wiki TARBP2
TARBP2, encoding a 345-amino acid protein termed TRBP by the authors. Mutation analysis showed that the TARBP2 protein binds to the helix between the bulge and the loop of the TAR RNA. Functional analysis demonstrated that TARBP2 enhanced expression of the HIV-1 LTR 20- to 60-fold and that the transactivation required an intact TAR RNA structure.
TARBP2 encodes 90- and 37-kD proteins in mouse cells, a 37-kD protein in hamster cells, and a 55-kD protein in monkey and human cells. TARBP2binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tar RNA Binding Protein 2 (TARBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tar RNA Binding Protein 2 (TARBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tar RNA Binding Protein 2 (TARBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tar RNA Binding Protein 2 (TARBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tar RNA Binding Protein 2 (TARBP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tar RNA Binding Protein 2 (TARBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tar RNA Binding Protein 2 (TARBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tar RNA Binding Protein 2 (TARBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tar RNA Binding Protein 2 (TARBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tar RNA Binding Protein 2 (TARBP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tar RNA Binding Protein 2 (TARBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tar RNA Binding Protein 2 (TARBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tar RNA Binding Protein 2 (TARBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tar RNA Binding Protein 2 (TARBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tar RNA Binding Protein 2 (TARBP2) ELISA Kit Customized Service Offer
  1. "Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR."Science 251:1597-1600(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1)."Genomics 25:66-72(1995) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line."J. Biol. Chem. 276:48803-48813(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen."Mol. Cell. Biol. 13:2193-2202(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression."J. Biol. Chem. 276:33899-33905(2001) [PubMed] [Europe PMC] [Abstract]
  7. "The TAR RNA-binding protein, TRBP, stimulates the expression of TAR-containing RNAs in vitro and in vivo independently of its ability to inhibit the dsRNA-dependent kinase PKR."J. Biol. Chem. 278:4440-4448(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing."Cell 123:631-640(2005) [PubMed] [Europe PMC] [Abstract]
  9. "TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing."EMBO Rep. 6:961-967(2005) [PubMed] [Europe PMC] [Abstract]
  10. "A human, ATP-independent, RISC assembly machine fueled by pre-miRNA."Genes Dev. 19:2979-2990(2005) [PubMed] [Europe PMC] [Abstract]
  11. "TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing."Nature 436:740-744(2005) [PubMed] [Europe PMC] [Abstract]
  12. "The role of PACT in the RNA silencing pathway."EMBO J. 25:522-532(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA."J. Biol. Chem. 282:17649-17657(2007) [PubMed] [Europe PMC] [Abstract]
  14. "RNA helicase A interacts with RISC in human cells and functions in RISC loading."Mol. Cell 26:523-537(2007) [PubMed] [Europe PMC] [Abstract]
  15. "MicroRNA silencing through RISC recruitment of eIF6."Nature 447:823-828(2007) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "In vitro reconstitution of the human RISC-loading complex."Proc. Natl. Acad. Sci. U.S.A. 105:512-517(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Interactions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions."RNA Biol. 5:92-103(2008) [PubMed] [Europe PMC] [Abstract]
  19. "A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function."Nat. Genet. 41:365-370(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Solution structure of the second DSRBD of TAR RNA-binding protein 2."Submitted (NOV-2005) to the PDB data bank