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TNFRSF1A Associated Via Death Domain Protein (TRADD)

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Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein; TNFRSF1A-associated via death domain

TNFRSF1A Associated Via Death Domain Protein (TRADD)
CCC M390
HGNC 12030
MGI 109200
PubMed 7758105
RGD 621313
UniProt Q15628
Wiki TRADD
TRADD is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. TRADD contains a 111-amino acid death domain with sequence similarity to that of TNFR1. The 1.4-kb TRADD mRNA is expressed ubiquitously.TRADD-mediated cell death could be suppressed by expression of the cowpox virus crmA gene, which encodes an inhibitor of ICE, a cysteine protease involved in TNF-induced apoptosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM390Hu01 Recombinant TNFRSF1A Associated Via Death Domain Protein (TRADD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM390Hu01 Polyclonal Antibody to TNFRSF1A Associated Via Death Domain Protein (TRADD) WB; IHC
Assay Kits SEM390Hu ELISA Kit for TNFRSF1A Associated Via Death Domain Protein (TRADD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM390Mu01 Recombinant TNFRSF1A Associated Via Death Domain Protein (TRADD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM390Mu01 Polyclonal Antibody to TNFRSF1A Associated Via Death Domain Protein (TRADD) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for TNFRSF1A Associated Via Death Domain Protein (TRADD) CLIA Kit Customized Service Offer
n/a ELISA Kit for TNFRSF1A Associated Via Death Domain Protein (TRADD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM390Ra01 Recombinant TNFRSF1A Associated Via Death Domain Protein (TRADD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM390Ra01 Polyclonal Antibody to TNFRSF1A Associated Via Death Domain Protein (TRADD) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for TNFRSF1A Associated Via Death Domain Protein (TRADD) CLIA Kit Customized Service Offer
n/a ELISA Kit for TNFRSF1A Associated Via Death Domain Protein (TRADD) ELISA Kit Customized Service Offer
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  9. "AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation."J. Biol. Chem. 279:44955-44965(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
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  12. "A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction."Cell 101:777-787(2000) [PubMed] [Europe PMC] [Abstract]