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tRNA-5-Methylaminomethyl-2-Thiouridylate Methyltransferase (TRMU)

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TRNT1; TRMT1; MTO2; MTU1; TRMT; Mitochondrial tRNA-specific 2-thiouridylase 1

tRNA-5-Methylaminomethyl-2-Thiouridylate Methyltransferase (TRMU)
CCC M401
HGNC 25481
MGI 1919276
PubMed 19732863
RGD 1311229
UniProt O75648
Wiki TRMU
TRMU is a member of the trmU family. It encodes a mitochondria-specific tRNA-modifying enzyme that is required for the 2-thio modification of 5-taurinomethyl-2-thiouridine tRNA-Lys on the wobble position of the anticodon.
The full-length 421-amino acid protein has a calculated molecular mass of 47.7 kD. The other transcripts lack exon 3 and encode a deduced 99-amino acid protein. Northern blot analysis detected high expression of a 1.9-kb TRMU transcript in heart, skeletal muscle, and kidney. Intermediate expression was detected in brain, placenta, spleen, and small intestine, and low expression was detected in liver, colon, lung, thymus, and leukocytes. Expression was nearly uniform in 8 brain regions examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant tRNA-5-Methylaminomethyl-2-Thiouridylate Methyltransferase (TRMU) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to tRNA-5-Methylaminomethyl-2-Thiouridylate Methyltransferase (TRMU) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to tRNA-5-Methylaminomethyl-2-Thiouridylate Methyltransferase (TRMU) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for tRNA-5-Methylaminomethyl-2-Thiouridylate Methyltransferase (TRMU) CLIA Kit Customized Service Offer
n/a ELISA Kit for tRNA-5-Methylaminomethyl-2-Thiouridylate Methyltransferase (TRMU) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant tRNA-5-Methylaminomethyl-2-Thiouridylate Methyltransferase (TRMU) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to tRNA-5-Methylaminomethyl-2-Thiouridylate Methyltransferase (TRMU) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to tRNA-5-Methylaminomethyl-2-Thiouridylate Methyltransferase (TRMU) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for tRNA-5-Methylaminomethyl-2-Thiouridylate Methyltransferase (TRMU) CLIA Kit Customized Service Offer
n/a ELISA Kit for tRNA-5-Methylaminomethyl-2-Thiouridylate Methyltransferase (TRMU) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant tRNA-5-Methylaminomethyl-2-Thiouridylate Methyltransferase (TRMU) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to tRNA-5-Methylaminomethyl-2-Thiouridylate Methyltransferase (TRMU) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to tRNA-5-Methylaminomethyl-2-Thiouridylate Methyltransferase (TRMU) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for tRNA-5-Methylaminomethyl-2-Thiouridylate Methyltransferase (TRMU) CLIA Kit Customized Service Offer
n/a ELISA Kit for tRNA-5-Methylaminomethyl-2-Thiouridylate Methyltransferase (TRMU) ELISA Kit Customized Service Offer
  1. "Human TRMU encoding the mitochondrial 5-methylaminomethyl-2-methyltransferase is a putative nuclear modifier gene for the phenotypic expression of the deafness-associated 12S rRNA mutations."Biochem. Biophys. Res. Commun. 342:1130-1136(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases."J. Biol. Chem. 280:1613-1624(2005) [PubMed] [Europe PMC] [Abstract]
  3. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in MTO2 related to tRNA modification impair mitochondrial gene expression and protein synthesis in the presence of a paromomycin resistance mutation in mitochondrial 15 S rRNA."J. Biol. Chem. 280:29151-29157(2005) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations." Am. J. Hum. Genet. 79:291-302(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Acute infantile liver failure due to mutations in the TRMU gene."Am. J. Hum. Genet. 85:401-407(2009) [PubMed] [Europe PMC] [Abstract]
  11. ErratumAm. J. Hum. Genet. 86:295-295(2010)