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TRAF And TNF Receptor Associated Protein (TTRAP)

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EAP2; TDP2; Tyrosyl-DNA Phosphodiesterase 2; 5'-tyrosyl-DNA phosphodiesterase; ETS1-associated protein 2; Tyrosyl-RNA phosphodiesterase; VPg unlinkase

TRAF And TNF Receptor Associated Protein (TTRAP)
CCC M408
HGNC 17768
MGI 1860486
PubMed 18356264
RGD 1560342
UniProt O95551
Wiki TTRAP
TTRAP encodes a member of a superfamily of divalent cation-dependent phosphodiesterases.TTRAP associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.The deduced 362-amino acid protein contains a potential coiled-coil motif between residues 236 and 250. Northern blot analysis detected a 2.2-kb transcript in all tissues tested, with an additional 1.8-kb transcript in testis. Northern blot and in situ hybridization analysis indicated ubiquitous but variable expression in adult and embryonic mouse tissues, with striking expression in fetal thymus and discrete brain regions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TRAF And TNF Receptor Associated Protein (TTRAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TRAF And TNF Receptor Associated Protein (TTRAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TRAF And TNF Receptor Associated Protein (TTRAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TRAF And TNF Receptor Associated Protein (TTRAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for TRAF And TNF Receptor Associated Protein (TTRAP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TRAF And TNF Receptor Associated Protein (TTRAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TRAF And TNF Receptor Associated Protein (TTRAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TRAF And TNF Receptor Associated Protein (TTRAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TRAF And TNF Receptor Associated Protein (TTRAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for TRAF And TNF Receptor Associated Protein (TTRAP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TRAF And TNF Receptor Associated Protein (TTRAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TRAF And TNF Receptor Associated Protein (TTRAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TRAF And TNF Receptor Associated Protein (TTRAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TRAF And TNF Receptor Associated Protein (TTRAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for TRAF And TNF Receptor Associated Protein (TTRAP) ELISA Kit Customized Service Offer
  1. "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation."J. Biol. Chem. 275:18586-18593(2000) [PubMed] [Europe PMC] [Abstract]
  2. "EAPII interacts with ETS1 and modulates its transcriptional function."Oncogene 22:2699-2709(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination."Development 134:4381-4393(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage."Nature 461:674-678(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage."J. Biol. Chem. 286:403-409(2011) [PubMed] [Europe PMC] [Abstract]
  12. "TTRAP is a novel component of the non-canonical TRAF6-TAK1 TGF-beta signaling pathway."PLoS ONE 6:E25548-E25548(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction."BMC Res. Notes 5:134-134(2012) [PubMed] [Europe PMC] [Abstract]
  14. "The PML nuclear bodies-associated protein TTRAP regulates ribosome biogenesis in nucleolar cavities upon proteasome inhibition."Cell Death Differ. 19:488-500(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Biochemical characterization of human Tyrosyl DNA Phosphodiesterase 2 (TDP2/TTRAP): a Mg2+/Mn2+-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes."J. Biol. Chem. 287:30842-30852(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  17. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An RNA virus hijacks an incognito function of a DNA repair enzyme."Proc. Natl. Acad. Sci. U.S.A. 109:14634-14639(2012) [PubMed] [Europe PMC] [Abstract]