Plasminogen Like Protein B (PLGLB)

The deduced 96-amino peptide has a calculated molecular mass of 11.2 kD. PRGB has signal sequence followed by a 77-amino acid stretch that is identical to the N terminus of plasminogen and highly similar to the homologous stretch in PRGA (PLGLA). PRGB is predicted to have 2 disulfide bonds and assume a secondary structure including an alpha helix and antiparallel beta sheet. Northern blot analysis using a probe that did not differentiate between PRGA and PRGB detected PRG only in liver and in a lymphoblastic leukemia cell line.

The 1.1-kb 5-prime flanking sequence directed basal liver-specific expression in HepG2 cells, and deletion analysis identified positive and negative elements in the PLGLB1 promoter.