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Autophagy/Beclin 1 Regulator 1 (AMBRA1)

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WDR94; DCAF3; WD Repeat Domain 94; DDB1 And CUL4 Associated Factor 3; Activating molecule in BECN1-regulated autophagy protein 1

Autophagy/Beclin 1 Regulator 1 (AMBRA1)
CCC M487
HGNC 25990
MGI 2443564
PubMed 23524951
UniProt Q9C0C7
AMBRA1 bound BECN1, a component of the class III phosphatidylinositol-3 kinase complex (VPS34, or PIK3C3;) that regulates autophagosome formation. Downregulation of AMBRA1 expression in a human fibrosarcoma cell line increased autophagy and the rate of cell proliferation. Conversely, overexpression of AMBRA1 decreased autophagy and the rate of cell proliferation. AMBRA1 downregulation also significantly reduced the ability of BECN1 to interact with VPS34.
Ambra1, which encodes a deduced 1,300-amino acid protein with an N-terminal WD40 domain. By database analysis, they identified and cloned human AMBRA1, which encodes a deduced 1,269-amino acid protein. Ambra1 was expressed throughout development in mice, with strong staining in the neuroepithelium.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Autophagy/Beclin 1 Regulator 1 (AMBRA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Autophagy/Beclin 1 Regulator 1 (AMBRA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Autophagy/Beclin 1 Regulator 1 (AMBRA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Autophagy/Beclin 1 Regulator 1 (AMBRA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Autophagy/Beclin 1 Regulator 1 (AMBRA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Autophagy/Beclin 1 Regulator 1 (AMBRA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Autophagy/Beclin 1 Regulator 1 (AMBRA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Autophagy/Beclin 1 Regulator 1 (AMBRA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Autophagy/Beclin 1 Regulator 1 (AMBRA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Autophagy/Beclin 1 Regulator 1 (AMBRA1) ELISA Kit Customized Service Offer
  1. "Ambra1 regulates autophagy and development of the nervous system."Nature 447:1121-1125(2007) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism."Cell 154:1085-1099(2013) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]