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Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3C (APOBEC3C)

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APOBEC1L; PBI; ARDC2; ARDC4; ARP5; DNA dC->dU-editing enzyme APOBEC-3C; APOBEC1-like; Phorbolin I

Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3C (APOBEC3C)
CCC M501
HGNC 17353
PubMed 23001005
UniProt Q9NRW3
Wiki APOBEC3C
APOBEC3C is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22.
The deduced 190-amino acid protein shares the overall domain structure of APOBEC1, including an active site, a linker region, and a pseudoactive site, but it lacks the N-terminal alpha helix. Northern blot analysis detected moderate to high expression in spleen, testis, peripheral blood leukocytes, heart, thymus, prostate, and ovary. Moderate to low expression was found in other tissues, including colon. APOBEC3C was expressed at high levels in colorectal adenocarcinoma and chronic myelogenous leukemia cells, and to a lesser extent in several other lymphoma and leukemia cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3C (APOBEC3C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3C (APOBEC3C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3C (APOBEC3C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3C (APOBEC3C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3C (APOBEC3C) ELISA Kit Customized Service Offer
  1. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22."Genomics 79:285-296(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif."Cell 114:21-31(2003) [PubMed] [Europe PMC] [Abstract]
  7. "APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication."J. Biol. Chem. 279:53379-53386(2004) [PubMed] [Europe PMC] [Abstract]
  8. "APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons."Curr. Biol. 16:480-485(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements."Annu. Rev. Immunol. 26:317-353(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Hepatitis B: modern concepts in pathogenesis--APOBEC3 cytidine deaminases as effectors in innate immunity against the hepatitis B virus."Curr. Opin. Infect. Dis. 21:298-303(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet."J. Biol. Chem. 284:5819-5826(2009) [PubMed] [Europe PMC] [Abstract]
  12. "APOBEC3 proteins mediate the clearance of foreign DNA from human cells."Nat. Struct. Mol. Biol. 17:222-229(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction."Nucleic Acids Res. 38:4274-4284(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain."Cell 145:423-434(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo."J. Virol. 85:7594-7602(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."J. Virol. 85:11220-11234(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Cytosine deaminases APOBEC3A, APOBEC3C, and APOBEC3H: Current understanding of their functional roles."Student Perspec. Contemp. Virol. 0:0-0(2011)
  18. "Retroelements versus APOBEC3 family members: No great escape from the magnificent seven."Front. Microbiol. 3:275-275(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A."J. Biol. Chem. 287:39182-39192(2012) [PubMed] [Europe PMC] [Abstract]
  20. "HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."J. Virol. 86:11712-11724(2012) [PubMed] [Europe PMC] [Abstract]
  21. "Functions and regulation of the APOBEC family of proteins."Semin. Cell Dev. Biol. 23:258-268(2012) [PubMed] [Europe PMC] [Abstract]