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Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3D (APOBEC3D)

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APOBEC3E; ARP6; A3D; DNA dC->dU-editing enzyme APOBEC-3D

Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3D (APOBEC3D)
CCC M502
HGNC 17354
PubMed 23001005
UniProt Q96AK3
Wiki APOBEC3D
APOBEC3D is 1 of several tandemly duplicated APOBEC1-like genes on chromosome 22 that encode cytidine-to-uridine RNA-editing deaminases.
The deduced 271-amino acid protein contains an N-terminal alpha helix, followed by a cytidine deaminase active site, a linker region, and a pseudoactive site. A region corresponding to intron 3 in other APOBEC3 genes is translated in APOBEC3D, producing an extended sequence between the linker region and the pseudoactive site. Northern blot analysis detected APOBEC3D expression in colorectal adenocarcinoma cells, chronic myelogenous leukemia cells, lung carcinoma, and HeLa cells. No expression was detected in normal tissues.APOBEC3D gene contains 3 exons. The promoter region contains no TATA or CATT box.

Organism species: Homo sapiens (Human)

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Antibodies n/a Monoclonal Antibody to Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3D (APOBEC3D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3D (APOBEC3D) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3D (APOBEC3D) CLIA Kit Customized Service Offer
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  1. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  2. "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22."Genomics 79:285-296(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business."Trends Genet. 19:207-216(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif."Cell 114:21-31(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements."Annu. Rev. Immunol. 26:317-353(2008) [PubMed] [Europe PMC] [Abstract]
  6. "APOBEC3 proteins mediate the clearance of foreign DNA from human cells."Nat. Struct. Mol. Biol. 17:222-229(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction."Nucleic Acids Res. 38:4274-4284(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."J. Virol. 85:11220-11234(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Retroelements versus APOBEC3 family members: No great escape from the magnificent seven."Front. Microbiol. 3:275-275(2012) [PubMed] [Europe PMC] [Abstract]
  10. "HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."J. Virol. 86:11712-11724(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n."PLoS Pathog. 8:E1002800-E1002800(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Functions and regulation of the APOBEC family of proteins."Semin. Cell Dev. Biol. 23:258-268(2012) [PubMed] [Europe PMC] [Abstract]
  13. "APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ t cells and macrophages."J. Virol. 87:444-453(2013) [PubMed] [Europe PMC] [Abstract]
  14. "The suppression of HIV-1 infection by APOBEC3 proteins in primary human CD4+ T cells is associated with the inhibition of processive reverse transcription as well as excessive cytidine deamination."J. Virol. 87:1508-1517(2013) [PubMed] [Europe PMC] [Abstract]