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Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3G (APOBEC3G)

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CEM15; ARCD; A3G; ARP-9; DNA dC->dU-editing enzyme APOBEC-3G; APOBEC-related cytidine deaminase; APOBEC-related protein 9; Deoxycytidine deaminase

Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3G (APOBEC3G)
CCC M504
HGNC 17357
PubMed 22190037
UniProt Q9HC16
Wiki APOBEC3G
APOBEC3G is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity.CEM15 contains the Prosite cytosine nucleoside/nucleotide deaminase zinc-binding motif PS00903. This zinc-binding domain has been identified in cytosine nucleoside/nucleotide deaminases present in organisms ranging from bacteriophages to humans and is critical for the catalytic activity of these enzymes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3G (APOBEC3G) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3G (APOBEC3G) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3G (APOBEC3G) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3G (APOBEC3G) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3G (APOBEC3G) ELISA Kit Customized Service Offer
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  13. "HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability."Mol. Cell 12:591-601(2003) [PubMed] [Europe PMC] [Abstract]
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  27. "APOBEC3G subunits self-associate via the C-terminal deaminase domain."J. Biol. Chem. 283:33329-33336(2008) [PubMed] [Europe PMC] [Abstract]
  28. "Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization."J. Virol. 82:9591-9599(2008) [PubMed] [Europe PMC] [Abstract]
  29. "Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif."Nat. Struct. Mol. Biol. 15:1184-1191(2008) [PubMed] [Europe PMC] [Abstract]
  30. "Restriction of equine infectious anemia virus by equine APOBEC3 cytidine deaminases."J. Virol. 83:7547-7559(2009) [PubMed] [Europe PMC] [Abstract]
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  33. "Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs."J. Virol. 84:5719-5729(2010) [PubMed] [Europe PMC] [Abstract]
  34. "Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction."Nucleic Acids Res. 38:4274-4284(2010) [PubMed] [Europe PMC] [Abstract]
  35. "APOBEC3G directly binds Hepatitis B virus core protein in cell and cell free systems."Virus Res. 151:213-219(2010) [PubMed] [Europe PMC] [Abstract]
  36. "Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein."J. Biol. Chem. 286:26568-26575(2011) [PubMed] [Europe PMC] [Abstract]
  37. "Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities."J. Virol. 85:1765-1776(2011) [PubMed] [Europe PMC] [Abstract]
  38. "Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."J. Virol. 85:11220-11234(2011) [PubMed] [Europe PMC] [Abstract]
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  42. "Retroelements versus APOBEC3 family members: No great escape from the magnificent seven."Front. Microbiol. 3:275-275(2012) [PubMed] [Europe PMC] [Abstract]
  43. "APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10."J. Biol. Chem. 287:29373-29383(2012) [PubMed] [Europe PMC] [Abstract]
  44. "The cellular antiviral protein APOBEC3G interacts with HIV-1 reverse transcriptase and inhibits its function during viral replication."J. Virol. 86:3777-3786(2012) [PubMed] [Europe PMC] [Abstract]
  45. "HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."J. Virol. 86:11712-11724(2012) [PubMed] [Europe PMC] [Abstract]
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  47. "Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment."Retrovirology 9:35-35(2012) [PubMed] [Europe PMC] [Abstract]
  48. "Functions and regulation of the APOBEC family of proteins."Semin. Cell Dev. Biol. 23:258-268(2012) [PubMed] [Europe PMC] [Abstract]
  49. "APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ t cells and macrophages."J. Virol. 87:444-453(2013) [PubMed] [Europe PMC] [Abstract]
  50. "The suppression of HIV-1 infection by APOBEC3 proteins in primary human CD4+ T cells is associated with the inhibition of processive reverse transcription as well as excessive cytidine deamination."J. Virol. 87:1508-1517(2013) [PubMed] [Europe PMC] [Abstract]
  51. "Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G."Nature 452:116-119(2008) [PubMed] [Europe PMC] [Abstract]
  52. "Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications."Nature 456:121-124(2008) [PubMed] [Europe PMC] [Abstract]
  53. "Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G."EMBO J. 28:440-451(2009) [PubMed] [Europe PMC] [Abstract]
  54. "First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G."ACS Chem. Biol. 7:506-517(2012) [PubMed] [Europe PMC] [Abstract]