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Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3H (APOBEC3H)

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ARP10; A3H; DNA dC->dU-editing enzyme APOBEC-3H; APOBEC-related protein 10

Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3H (APOBEC3H)
CCC M505
HGNC 24100
PubMed 12683974
UniProt Q6NTF7
Wiki APOBEC3H
APOBEC3H encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.
In contrast, human APOBEC3H was poorly expressed at the protein level in human embryonic kidney cells and was ineffective at inhibiting retroviral replication. Poor expression of APOBEC3H was due to elevated degradation by proteasomes and not to reduced mRNA levels or protein translation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3H (APOBEC3H) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3H (APOBEC3H) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3H (APOBEC3H) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3H (APOBEC3H) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide 3H (APOBEC3H) ELISA Kit Customized Service Offer
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  5. "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business."Trends Genet. 19:207-216(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Adaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3H."J. Virol. 80:3853-3862(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC family."J. Virol. 80:10522-10533(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements."Annu. Rev. Immunol. 26:317-353(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Antiretroelement activity of APOBEC3H was lost twice in recent human evolution."Cell Host Microbe 4:249-259(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Human cytidine deaminase APOBEC3H restricts HIV-1 replication."J. Biol. Chem. 283:11606-11614(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Sole copy of Z2-type human cytidine deaminase APOBEC3H has inhibitory activity against retrotransposons and HIV-1."FASEB J. 23:279-287(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction."Nucleic Acids Res. 38:4274-4284(2010) [PubMed] [Europe PMC] [Abstract]
  13. "APOBEC3 proteins mediate the clearance of foreign DNA from human cells."Nat. Struct. Mol. Biol. 17:222-229(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Polymorphism in human APOBEC3H affects a phenotype dominant for subcellular localization and antiviral activity."J. Virol. 85:8197-8207(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."J. Virol. 85:11220-11234(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Cytosine deaminases APOBEC3A, APOBEC3C, and APOBEC3H: Current understanding of their functional roles."Student Perspec. Contemp. Virol. 0:0-0(2011)
  17. "Retroelements versus APOBEC3 family members: No great escape from the magnificent seven."Front. Microbiol. 3:275-275(2012) [PubMed] [Europe PMC] [Abstract]
  18. "APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1."J. Virol. 86:6097-6108(2012) [PubMed] [Europe PMC] [Abstract]
  19. "HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."J. Virol. 86:11712-11724(2012) [PubMed] [Europe PMC] [Abstract]
  20. "Functions and regulation of the APOBEC family of proteins."Semin. Cell Dev. Biol. 23:258-268(2012) [PubMed] [Europe PMC] [Abstract]
  21. "APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ t cells and macrophages."J. Virol. 87:444-453(2013) [PubMed] [Europe PMC] [Abstract]