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Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20)

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RBSN; Rabenosyn-5; 110 kDa protein; FYVE finger-containing Rab5 effector protein rabenosyn-5

Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20)
CCC M530
HGNC 20759
MGI 1925537
PubMed 11062261
RGD 1305397
UniProt Q9H1K0
Wiki ZFYVE20
Rabenosyn-5 colocalized with EEA1 on RAB5-positive endosomes in HeLa cells. Mutation analysis indicated that the FYVE domain of rabenosyn-5 was required for endosome targeting. Rabenosyn-5 was complexed with the Sec1-like protein VPS45 (VPS45A), and rabenosyn-5 appeared to serve as a molecular link between VPS45 and RAB5. Both EEA1 and rabenosyn-5 were required for early endosomal fusion, but only rabenosyn-5 overexpression inhibited processing of procathepsin D to its 47-kD intermediate, suggesting that the 2 proteins play distinct roles in endosomal trafficking.The deduced 784-amino acid protein contains an N-terminal C2H2-type zinc finger domain, a central FYVE finger domain, and 5 copies of the amino acid motif NPF at its C terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, FYVE Domain Containing Protein 20 (ZFYVE20) ELISA Kit Customized Service Offer
  1. "Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain."J. Cell Biol. 151:601-612(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes."Nat. Cell Biol. 4:124-133(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane."Mol. Biol. Cell 15:2410-2422(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis."Proc. Natl. Acad. Sci. U.S.A. 109:E471-E480(2012) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Structural basis of family-wide Rab GTPase recognition by rabenosyn-5."Nature 436:415-419(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking."Orphanet J. Rare Dis. 9:141-141(2014) [PubMed] [Europe PMC] [Abstract]