Annexin II Receptor (AX2R)

AX2R was transcribed in most tissues examined, except heart, brain, and skeletal muscle. Its expression level was comparable in CD4(+)- and CD8(+)-expressing T cells but decreased in activated CD8+ T cells. An antibody to the AX2R protein blocked the effects of annexin II on human osteoclast formation in a dose-dependent manner. Pools from a human marrow cDNA library were transfected into NIH3T3 cells and screened for any that bound radiolabeled annexin II tetramer. The receptor clone, AX2R, was isolated and further characterized. The deduced AX2R protein is a type I transmembrane protein with 1 transmembrane domain. It contains 193-amino acids, only 4 of which are in the cytoplasmic tail, and has a molecular mass of 26 kD; thus, the 55-kD complex first identified may include 2 p11 subunits