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ATR Interacting Protein (ATRIP)

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AGS1; ATM and Rad3-related-interacting protein

ATR Interacting Protein (ATRIP)
CCC M600
HGNC 33499
MGI 1925349
PubMed 11721054
RGD 1626390
UniProt Q8WXE1
ATRIP is an essential component of the DNA damage checkpoint, and binds to single-stranded DNA coated with replication protein A that accumulates at sites of DNA damage. The encoded protein interacts with the ataxia telangiectasia and Rad3 related protein, a checkpoint kinase, resulting in accumulation of the kinase at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.ATRIP is phosphorylated by ATR, regulates ATR expression, and is an essential component of the DNA damage checkpoint pathway. Deletion of ATR mediated by the Cre recombinase caused the loss of ATR and ATRIP expression, loss of DNA damage checkpoint responses, and cell death. Therefore, ATR is essential for the viability of human somatic cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATR Interacting Protein (ATRIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATR Interacting Protein (ATRIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATR Interacting Protein (ATRIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATR Interacting Protein (ATRIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATR Interacting Protein (ATRIP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATR Interacting Protein (ATRIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATR Interacting Protein (ATRIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATR Interacting Protein (ATRIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATR Interacting Protein (ATRIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATR Interacting Protein (ATRIP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATR Interacting Protein (ATRIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATR Interacting Protein (ATRIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATR Interacting Protein (ATRIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATR Interacting Protein (ATRIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATR Interacting Protein (ATRIP) ELISA Kit Customized Service Offer
  1. "ATR and ATRIP: partners in checkpoint signaling."Science 294:1713-1716(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes."Science 300:1542-1548(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage."Nature 434:605-611(2005) [PubMed] [Europe PMC] [Abstract]
  8. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1."Genes Dev. 22:587-600(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Functional genomic screens identify CINP as a genome maintenance protein."Proc. Natl. Acad. Sci. U.S.A. 106:19304-19309(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]