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Cardiac Specific Homeobox 2 (CSX2)

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NKX2-6; NKX4-2; NK2 Transcription Factor Related Locus 6; Tinman Paralog; Homeobox protein NK-2 homolog F

Cardiac Specific Homeobox 2 (CSX2)
CCC M620
HGNC 32940
MGI 97351
RGD 1306149
UniProt A6NCS4
Homeobox-containing genes play critical roles in regulating tissue-specific gene expression essential for tissue differentiation, as well as determining the temporal and spatial patterns of development. It has been demonstrated that a Drosophila homeobox-containing gene called 'tinman' is essential for development of the heart-like dorsal vessel. NKX2-6 is a vertebrate homolog of 'tinman' (Newman and Krieg, 1998).
In mouse Nkx2-6 is expressed between embryonic day 8.5 and 10.5 with expression detected in all 3 layers of the caudal branchial arches.F151L-homozygous mice were normal, but that Nkx2-5 (600584) expression expanded into regions lacking Nkx2-6, suggesting functional complementation

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cardiac Specific Homeobox 2 (CSX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cardiac Specific Homeobox 2 (CSX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cardiac Specific Homeobox 2 (CSX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cardiac Specific Homeobox 2 (CSX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cardiac Specific Homeobox 2 (CSX2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cardiac Specific Homeobox 2 (CSX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cardiac Specific Homeobox 2 (CSX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cardiac Specific Homeobox 2 (CSX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cardiac Specific Homeobox 2 (CSX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cardiac Specific Homeobox 2 (CSX2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cardiac Specific Homeobox 2 (CSX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cardiac Specific Homeobox 2 (CSX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cardiac Specific Homeobox 2 (CSX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cardiac Specific Homeobox 2 (CSX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cardiac Specific Homeobox 2 (CSX2) ELISA Kit Customized Service Offer
  1. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation."Nat. Biotechnol. 22:707-716(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Common arterial trunk associated with a homeodomain mutation of NKX2.6."Hum. Mol. Genet. 14:585-593(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Prevalence and spectrum of Nkx2.6 mutations in patients with congenital heart disease."Eur. J. Med. Genet. 57:579-586(2014) [PubMed] [Europe PMC] [Abstract]
  5. "Conotruncal malformations and absent thymus due to a deleterious NKX2-6 mutation."J. Med. Genet. 51:268-270(2014) [PubMed] [Europe PMC] [Abstract]
  6. "A novel NKX2.6 mutation associated with congenital ventricular septal defect."Pediatr. Cardiol. 36:646-656(2015) [PubMed] [Europe PMC] [Abstract]