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Lin-28 Homolog B (LIN28B)

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CSDD2

Lin-28 Homolog B (LIN28B)
CCC M625
HGNC 32207
MGI 3584032
PubMed 21625210
RGD 1597432
UniProt Q6ZN17
contains the conserved combination of RNA-binding motifs of the C. elegans lin28 protein, a regulator of developmental timing, and human LIN28: a cold shock domain and a pair of retroviral-type CCHC zinc finger domains. mouse Lin28b, which encodes a predicted 271-amino acid protein that shares approximately 78% sequence identity with human LIN28B. RT-PCR analysis revealed high expression of LIN28B in normal human testis, fetal liver, and placenta,as well as in liver tumors from 9 pairs of tumor/nontumor samples. Northern blot analysis detected a 5.6-kb transcript highly expressed in 6 HCC cell lines. Guo et al. (2006) identified a second LIN28B isoform of 180 amino acids, designated LIN28BS, which was produced by alternative splicing and was present in nontumor liver tissue and fetal liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lin-28 Homolog B (LIN28B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lin-28 Homolog B (LIN28B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lin-28 Homolog B (LIN28B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lin-28 Homolog B (LIN28B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lin-28 Homolog B (LIN28B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lin-28 Homolog B (LIN28B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lin-28 Homolog B (LIN28B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lin-28 Homolog B (LIN28B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lin-28 Homolog B (LIN28B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lin-28 Homolog B (LIN28B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lin-28 Homolog B (LIN28B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lin-28 Homolog B (LIN28B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lin-28 Homolog B (LIN28B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lin-28 Homolog B (LIN28B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lin-28 Homolog B (LIN28B) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma."Gene 384:51-61(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA."Mol. Cell 32:276-284(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "TUT4 in concert with Lin28 suppresses MicroRNA biogenesis through pre-microRNA uridylation."Cell 138:696-708(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Lin28 promotes transformation and is associated with advanced human malignancies." Nat. Genet. 41:843-848(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "The Lin28 cold-shock domain remodels pre-let-7 microRNA."Nucleic Acids Res. 40:7492-7506(2012) [PubMed] [Europe PMC] [Abstract]