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Defensin Beta 103B (DEFB103B)

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HBP3; HBD3; BD3; DEFB103; DEFB3; Defensin-like protein; Beta-defensin 3

Defensin Beta 103B (DEFB103B)
CCC M658
HGNC 31702
UniProt P81534
Two classes of defensins, alpha and beta, differ in their disulfide bond pairing, genomic organization, and tissue distribution. Alpha-defensins are expressed in neutrophils and in Paneth cells and other epithelia, and beta-defensins are expressed in epithelia. Epithelial beta-defensins are broad-spectrum cationic antimicrobial peptides. They may also act as chemokines for immature dendritic cells and memory T cells via CCR6, bridging the innate and adaptive immune systems. DEFB103 belongs to the beta class of defensins. The predicted 67-amino acid DEFB3 protein is 43% identical to DEFB2 and has the 6-cysteine motif typical of beta-defensins. PCR analysis of cDNA panels revealed expression in adult heart, skeletal muscle, and placenta as well as in fetal thymus. RNA dot blot analysis detected expression most readily in esophagus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM658Hu01 Recombinant Defensin Beta 103B (DEFB103B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM658Hu01 Polyclonal Antibody to Defensin Beta 103B (DEFB103B) WB; IHC; ICC; IP.
MAM658Hu21 Monoclonal Antibody to Defensin Beta 103B (DEFB103B) WB; IHC; ICC; IP.
Assay Kits SEM658Hu ELISA Kit for Defensin Beta 103B (DEFB103B) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic."J. Biol. Chem. 276:5707-5713(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction."Cell Tissue Res. 306:257-264(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Discovery of new human beta-defensins using a genomics-based approach."Gene 263:211-218(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus."J. Biol. Chem. 277:8279-8289(2002) [PubMed] [Europe PMC] [Abstract]