≡

ATPase Family, AAA Domain Containing Protein 2 (ATAD2)

[Edit]

ANCCA; AAA nuclear coregulator cancer-associated protein

ATPase Family, AAA Domain Containing Protein 2 (ATAD2)
CCC M663
HGNC 30123
MGI 1917722
PubMed 19843847
RGD 1304849
UniProt Q6PL18
The deduced 1,390-amino acid protein contains an N-terminal acidic region, followed by 2 AAA ATPase domains, and a bromodomain. Northern blot analysis detected ANCCA transcripts of 5 and 4.7 kb in estrogen-stimulated breast cancer cells. Western blot analysis revealed a 170-kD ANCCA protein. Immunofluorescence analysis showed ANCCA localized primarily in the nucleus.
ANCCA bound and hydrolyzed ATP and was critical for recruitment of coregulator CBP and histone hyperacetylation at the ER target chromatin. Mutation of lys473 and glu532 within the Walker A and Walker B motifs, respectively, of AAA domain-1 of ANCCA rendered ANCCA defective as a coactivator in mediating estrogen induction of gene expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATPase Family, AAA Domain Containing Protein 2 (ATAD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATPase Family, AAA Domain Containing Protein 2 (ATAD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATPase Family, AAA Domain Containing Protein 2 (ATAD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATPase Family, AAA Domain Containing Protein 2 (ATAD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATPase Family, AAA Domain Containing Protein 2 (ATAD2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATPase Family, AAA Domain Containing Protein 2 (ATAD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATPase Family, AAA Domain Containing Protein 2 (ATAD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATPase Family, AAA Domain Containing Protein 2 (ATAD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATPase Family, AAA Domain Containing Protein 2 (ATAD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATPase Family, AAA Domain Containing Protein 2 (ATAD2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATPase Family, AAA Domain Containing Protein 2 (ATAD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATPase Family, AAA Domain Containing Protein 2 (ATAD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATPase Family, AAA Domain Containing Protein 2 (ATAD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATPase Family, AAA Domain Containing Protein 2 (ATAD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATPase Family, AAA Domain Containing Protein 2 (ATAD2) ELISA Kit Customized Service Offer
  1. "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer."Oncogene 23:7734-7745(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs."Genome Res. 11:1392-1403(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer."Lancet 365:671-679(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A consensus prognostic gene expression classifier for ER positive breast cancer."Genome Biol. 7:R101.1-R101.13(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery."Mol. Cancer 5:20-20(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Prognostic significance of drug-regulated genes in high-grade osteosarcoma."Mod. Pathol. 20:1085-1094(2007) [PubMed] [Europe PMC] [Abstract]
  11. "ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification."Proc. Natl. Acad. Sci. U.S.A. 104:18067-18072(2007) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Histone recognition and large-scale structural analysis of the human bromodomain family."Cell 149:214-231(2012) [PubMed] [Europe PMC] [Abstract]