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PRELI Domain Containing Protein 1 (PRELID1)

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CGI-106; PX19; PRELI; SBBI12; 25 kDa protein of relevant evolutionary and lymphoid interest; Protein Of Relevant Evolutionary And Lymphoid Interest; Px19-Like Protein

PRELI Domain Containing Protein 1 (PRELID1)
CCC M676
HGNC 30255
MGI 1913744
PubMed 22174923
RGD 1308082
UniProt Q9Y255
The predicted 219-amino acid human protein is 85% identical to the avian protein. PX19 contains 2 alpha helices with amphipathic domains in opposite orientation, and the LEA motifs (A/TAEKAK) are clustered within this region.
Northern blot analysis detected 1.0- and 1.2-kb transcripts predominantly in fetal liver, with much lower levels in other fetal tissues. Expression was significantly reduced in adult liver, but was higher in other adult organs. Expression was low in bone marrow and thymus, but high in adult spleen, lymph node, and peripheral blood leukocytes. Further analysis of B-cell lines indicated that expression was higher in mature B cells, predominantly from germinal centers, and absent in progenitor and precursor B-cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PRELI Domain Containing Protein 1 (PRELID1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PRELI Domain Containing Protein 1 (PRELID1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PRELI Domain Containing Protein 1 (PRELID1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PRELI Domain Containing Protein 1 (PRELID1) CLIA Kit Customized Service Offer
n/a ELISA Kit for PRELI Domain Containing Protein 1 (PRELID1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PRELI Domain Containing Protein 1 (PRELID1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PRELI Domain Containing Protein 1 (PRELID1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PRELI Domain Containing Protein 1 (PRELID1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PRELI Domain Containing Protein 1 (PRELID1) CLIA Kit Customized Service Offer
n/a ELISA Kit for PRELI Domain Containing Protein 1 (PRELID1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PRELI Domain Containing Protein 1 (PRELID1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PRELI Domain Containing Protein 1 (PRELID1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PRELI Domain Containing Protein 1 (PRELID1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PRELI Domain Containing Protein 1 (PRELID1) CLIA Kit Customized Service Offer
n/a ELISA Kit for PRELI Domain Containing Protein 1 (PRELID1) ELISA Kit Customized Service Offer
  1. "PRELI, the human homologue of the avian px19, is expressed by germinal center B lymphocytes."Int. Immunol. 12:607-612(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "PRELI (protein of relevant evolutionary and lymphoid interest) is located within an evolutionarily conserved gene cluster on chromosome 5q34-q35 and encodes a novel mitochondrial protein."Biochem. J. 378:817-825(2004) [PubMed] [Europe PMC] [Abstract]
  8. "PRELI is a mitochondrial regulator of human primary T-helper cell apoptosis, STAT6, and Th2-cell differentiation."Blood 113:1268-1277(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Vital function of PRELI and essential requirement of its LEA motif."Cell Death Dis. 1:E21-E21(2010) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  11. "TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid."Cell Metab. 18:287-295(2013) [PubMed] [Europe PMC] [Abstract]