≡

Enolase Superfamily, Member 1 (ENOSF1)

[Edit]

HSRTSBETA; rTS; TYMSAS; Antisense RNA to thymidylate synthase; Mitochondrial enolase superfamily member 1

Enolase Superfamily, Member 1 (ENOSF1)
CCC M696
HGNC 30365
UniProt Q7L5Y1
ENOSF1 was originally identified as a naturally occurring antisense transcript to the human thymidylate synthase gene. Other transcript variants (rTSbeta and rTSgamma) do not overlap the TS locus.
The function of this gene appears to be primarily to regulate expression of the TS locus both via the antisense transcript as well as through the encoded proteins.All of TS exon 7 and part of intron 6 are overlapped by 3-prime rTS. Northern blot analysis of fractionated KB cells and other carcinoma cell lines revealed rTS transcripts of 1.8 and 6.3 kb, as well as several larger mRNA species. The presence and relative abundance of the larger transcripts varied between cell lines, and in vitro translation generated multiple translation products.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Enolase Superfamily, Member 1 (ENOSF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Enolase Superfamily, Member 1 (ENOSF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Enolase Superfamily, Member 1 (ENOSF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Enolase Superfamily, Member 1 (ENOSF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Enolase Superfamily, Member 1 (ENOSF1) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a naturally occurring antisense RNA to human thymidylate synthase mRNA."Nucleic Acids Res. 21:1747-1752(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Alternate splicing of the rTS gene product and its overexpression in a 5-fluorouracil-resistant cell line."Cancer Res. 56:3207-3210(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "rTS gene expression is associated with altered cell sensitivity to thymidylate synthase inhibitors."Adv. Enzyme Regul. 36:165-180(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Natural antisense (rTSalpha) RNA induces site-specific cleavage of thymidylate synthase mRNA."Biochim. Biophys. Acta 1587:183-193(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Comparative genomic analysis reveals a novel mitochondrial isoform of human rTS protein and unusual phylogenetic distribution of the rTS gene."BMC Genomics 6:125-125(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Enhancement of 5-fluorouracil sensitivity by an rTS signaling mimic in H630 colon cancer cells."Cancer Res. 65:5917-5924(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Enzymatic and structural characterization of rTSgamma provides insights into the function of rTSbeta."Biochemistry 53:2732-2738(2014) [PubMed] [Europe PMC] [Abstract]