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Spermatogenic Leucine Zipper 1 (SPZ1)

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NYD-TSP1; Testis-specific protein 1

Spermatogenic Leucine Zipper 1 (SPZ1)
CCC M736
HGNC 30721
MGI 1930801
PubMed 22402494
RGD 1562395
UniProt Q9BXG8
Wiki SPZ1
A novel bHLH-Zip gene designated Spz1 from a mouse testis cDNA library. Spz1 is expressed specifically in the testis and epididymis. Immunofluorescence staining detected Spz1 protein in the nuclei of LFG6 Leydig cells.
The ability of Spz1 protein to bind to the bHLH consensus-binding site, the E-box, was confirmed by EMSA, and a 9-bp asymmetric target site was identified by random selection and PCR amplification. Hormonal regulation of Spz1 was investigated and downregulation of Spz1 expression by testosterone and retinoic acid was found. This nuclear transcription factor may play a crucial role in spermatogenesis by regulating cell proliferation or differentiation through binding to specific DNA sequences like other bHLH-Zip molecules.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spermatogenic Leucine Zipper 1 (SPZ1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spermatogenic Leucine Zipper 1 (SPZ1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spermatogenic Leucine Zipper 1 (SPZ1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spermatogenic Leucine Zipper 1 (SPZ1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spermatogenic Leucine Zipper 1 (SPZ1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spermatogenic Leucine Zipper 1 (SPZ1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spermatogenic Leucine Zipper 1 (SPZ1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spermatogenic Leucine Zipper 1 (SPZ1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spermatogenic Leucine Zipper 1 (SPZ1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spermatogenic Leucine Zipper 1 (SPZ1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spermatogenic Leucine Zipper 1 (SPZ1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spermatogenic Leucine Zipper 1 (SPZ1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spermatogenic Leucine Zipper 1 (SPZ1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spermatogenic Leucine Zipper 1 (SPZ1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spermatogenic Leucine Zipper 1 (SPZ1) ELISA Kit Customized Service Offer
  1. "Expression of a novel bHLH-Zip gene in human testis."Asian J. Androl. 5:83-88(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis."Cancer Res. 65:4041-4050(2005) [PubMed] [Europe PMC] [Abstract]