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Serine/Threonine Kinase Receptor Associated Protein (STRAP)

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UNRIP; Pt-wd; MAWD; MAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WD

Serine/Threonine Kinase Receptor Associated Protein (STRAP)
CCC M748
HGNC 30796
MGI 1329037
PubMed 22362889
RGD 1311114
UniProt Q9Y3F4
Spliceosomal uridine-rich small nuclear ribonucleoprotein (snRNP) assembly is an active process mediated by the macromolecular SMN complex. This complex contains the SMN1 protein and 6 additional proteins named GEMIN2 (SIP1) to GEMIN7, according to their localization to nuclear structures termed gems.UNRIP is integrated into a complex with UNR or with the SMN complex in vivo in a mutually exclusive manner. In the latter case, UNRIP is recruited to the active SMN complex via a stable interaction with GEMIN7. However, unlike SMN and the gemins, UNRIP localized predominantly to the cytoplasm and was absent from gems/Cajal bodies. RNAi-induced reduction of UNRIP protein levels led to enhanced accumulation of SMN in the nucleus as evident by the increased formation of nuclear gems/Cajal bodies.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Threonine Kinase Receptor Associated Protein (STRAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Threonine Kinase Receptor Associated Protein (STRAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Threonine Kinase Receptor Associated Protein (STRAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Threonine Kinase Receptor Associated Protein (STRAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Threonine Kinase Receptor Associated Protein (STRAP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Threonine Kinase Receptor Associated Protein (STRAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Threonine Kinase Receptor Associated Protein (STRAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Threonine Kinase Receptor Associated Protein (STRAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Threonine Kinase Receptor Associated Protein (STRAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Threonine Kinase Receptor Associated Protein (STRAP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Threonine Kinase Receptor Associated Protein (STRAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Threonine Kinase Receptor Associated Protein (STRAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Threonine Kinase Receptor Associated Protein (STRAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Threonine Kinase Receptor Associated Protein (STRAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Threonine Kinase Receptor Associated Protein (STRAP) ELISA Kit Customized Service Offer
  1. "unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA."Genes Dev. 13:437-448(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of human MAWD, a novel protein containing WD-40 repeats frequently overexpressed in breast cancer."Cancer Res. 60:13-17(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. , Submitted (MAR-2007) to UniProtKB
  8. "Unrip is a component of SMN complexes active in snRNP assembly."FEBS Lett. 579:2348-2354(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization."Hum. Mol. Genet. 14:3099-3111(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein."J. Biol. Chem. 280:42897-42908(2005) [PubMed] [Europe PMC] [Abstract]
  11. "An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs."Cell 135:497-509(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]