≡

Asparagine Linked Glycosylation Protein 13 (ALG13)

[Edit]

GLT28D1; CXorf45; Glycosyltransferase 28 Domain Containing 1; Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13

Asparagine Linked Glycosylation Protein 13 (ALG13)
CCC M759
HGNC 30881
MGI 1914824
PubMed 16100110
UniProt Q9NP73
Wiki ALG13
ALG13 is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene.
The deduced 161-amino acid protein has a calculated molecular mass of 18.2 kD and shares 28% amino acid identity with yeast Alg13. Alg13 contains a predicted catalytic domain but lacks a membrane-spanning domain. Fluorescence microscopy and subcellular fractionation studies localized the S. cerevisiae Alg13 protein to the endoplasmic reticulum membrane.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Asparagine Linked Glycosylation Protein 13 (ALG13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Asparagine Linked Glycosylation Protein 13 (ALG13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Asparagine Linked Glycosylation Protein 13 (ALG13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Asparagine Linked Glycosylation Protein 13 (ALG13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Asparagine Linked Glycosylation Protein 13 (ALG13) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Asparagine Linked Glycosylation Protein 13 (ALG13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Asparagine Linked Glycosylation Protein 13 (ALG13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Asparagine Linked Glycosylation Protein 13 (ALG13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Asparagine Linked Glycosylation Protein 13 (ALG13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Asparagine Linked Glycosylation Protein 13 (ALG13) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation."J. Biol. Chem. 280:36254-36262(2005) [PubMed] [Europe PMC] [Abstract]
  5. "OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis."Cell 154:169-184(2013) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Gene identification in the congenital disorders of glycosylation type I by whole-exome sequencing."Hum. Mol. Genet. 21:4151-4161(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]