By sequencing clones obtained from a size-fractionated brain cDNA library, Nagase et al. (1997) obtained a partial cDNA encoding CLEC16A, which they designated KIAA0350. RT-PCR detected CLEC16A expression in all tissues examined, with highest levels in kidney, testis, and ovary. Nakajima et al. extended the partial KIAA0350 sequence and found that the deduced full-length protein contains 1,062 amino acids.
In addition to confirming previously identified loci, they found that type 1 diabetes was significantly associated with variation within a 233-kb linkage disequilibrium block on chromosome 16p13 that contains the KIAA0350 gene, which is predicted to encode a sugar-binding, C-type lectin.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant C-Type Lectin Domain Family 16, Member A (CLEC16A) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to C-Type Lectin Domain Family 16, Member A (CLEC16A) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to C-Type Lectin Domain Family 16, Member A (CLEC16A) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for C-Type Lectin Domain Family 16, Member A (CLEC16A) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for C-Type Lectin Domain Family 16, Member A (CLEC16A) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant C-Type Lectin Domain Family 16, Member A (CLEC16A) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to C-Type Lectin Domain Family 16, Member A (CLEC16A) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to C-Type Lectin Domain Family 16, Member A (CLEC16A) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for C-Type Lectin Domain Family 16, Member A (CLEC16A) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for C-Type Lectin Domain Family 16, Member A (CLEC16A) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant C-Type Lectin Domain Family 16, Member A (CLEC16A) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to C-Type Lectin Domain Family 16, Member A (CLEC16A) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to C-Type Lectin Domain Family 16, Member A (CLEC16A) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for C-Type Lectin Domain Family 16, Member A (CLEC16A) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for C-Type Lectin Domain Family 16, Member A (CLEC16A) | ELISA Kit Customized Service Offer |
- "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
- "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene." Nature 448:591-594(2007) [PubMed] [Europe PMC] [Abstract]
- "The diabetes susceptibility gene Clec16a regulates mitophagy."Cell 157:1577-1590(2014) [PubMed] [Europe PMC] [Abstract]