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Protein Phosphatase 1, Regulatory Subunit 18 (PPP1R18)

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Phostensin; Protein Phosphatase 1 F-Actin Cytoskeleton-Targeting Subunit

Protein Phosphatase 1, Regulatory Subunit 18 (PPP1R18)
CCC M830
HGNC 29413
MGI 1923698
PubMed 11853319
RGD 1309543
UniProt Q6NYC8
Wiki KIAA1949
Protein phosphatase-1 (PP1) interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin cytoskeleton. RT-PCR ELISA detected highest expression in spleen, followed by lung, liver, and ovary. Moderate expression was detected in all other adult and fetal tissues and specific brain regions examined. Phostensin interacted with PP1-alpha in transfected 293T and COS-7 cells. Pull-down assays showed that mutations in the PP1-binding motif of phostensin disrupted its interaction with PP1-alpha. Immunofluorescence analysis of transfected MDCK cells showed colocalization of PP1-alpha with phostensin at adherens junctions, a region rich in F-actin cytoskeleton.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 1, Regulatory Subunit 18 (PPP1R18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 18 (PPP1R18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 18 (PPP1R18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 1, Regulatory Subunit 18 (PPP1R18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 1, Regulatory Subunit 18 (PPP1R18) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 1, Regulatory Subunit 18 (PPP1R18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 18 (PPP1R18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 18 (PPP1R18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 1, Regulatory Subunit 18 (PPP1R18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 1, Regulatory Subunit 18 (PPP1R18) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 1, Regulatory Subunit 18 (PPP1R18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 18 (PPP1R18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 18 (PPP1R18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 1, Regulatory Subunit 18 (PPP1R18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 1, Regulatory Subunit 18 (PPP1R18) ELISA Kit Customized Service Offer
  1. "Identification of phostensin, a PP1 F-actin cytoskeleton targeting subunit."Biochem. Biophys. Res. Commun. 356:594-598(2007) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Identification of the high molecular weight isoform of phostensin."Int. J. Mol. Sci. 15:1068-1079(2014) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]