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DEXH Box Polypeptide 58 (DHX58)

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LGP2; D11LGP2; RNA Helicase LGP2; Asp-Glu-X-His Box Polypeptide 58; Probable ATP-dependent RNA helicase DHX58; Protein D11Lgp2 homolog; RIG-I-like receptor 3

DEXH Box Polypeptide 58 (DHX58)
CCC M852
HGNC 29517
MGI 1931560
PubMed 20950133
RGD 1310093
UniProt Q96C10
Wiki DHX58
LGP2 contain 678 amino acids and have a DEAD/H box domain and a C-terminal helicase domain. The DEAD/H box domain contains a conserved ATP-binding motif, an ATPase motif, and an unwinding motif, and the helicase domain contains an RNA-binding motif.
Mouse and human LGP2 share 79% amino acid identity. Northern blot analysis detected a 2.4-kb Lgp2 transcript expressed at highest levels in mouse testis and liver. Lower levels were detected in mammary tissue, heart, spleen, and lung, with little to no expression in other tissues examined. Immunohistochemical analysis detected mouse Lgp2 evenly distributed in the cytoplasm of transfected HeLa cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEXH Box Polypeptide 58 (DHX58) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEXH Box Polypeptide 58 (DHX58) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEXH Box Polypeptide 58 (DHX58) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEXH Box Polypeptide 58 (DHX58) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEXH Box Polypeptide 58 (DHX58) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEXH Box Polypeptide 58 (DHX58) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEXH Box Polypeptide 58 (DHX58) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEXH Box Polypeptide 58 (DHX58) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEXH Box Polypeptide 58 (DHX58) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEXH Box Polypeptide 58 (DHX58) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEXH Box Polypeptide 58 (DHX58) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEXH Box Polypeptide 58 (DHX58) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEXH Box Polypeptide 58 (DHX58) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEXH Box Polypeptide 58 (DHX58) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEXH Box Polypeptide 58 (DHX58) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity."J. Immunol. 175:2851-2858(2005) [PubMed] [Europe PMC] [Abstract]
  4. "RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2."J. Virol. 80:12332-12342(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2."Proc. Natl. Acad. Sci. U.S.A. 104:582-587(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of interferon production by RIG-I and LGP2: a lesson in self-control."Sci. STKE 2007:PE20-PE20(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response."J. Biol. Chem. 283:15825-15833(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2."J. Biol. Chem. 284:9700-9712(2009) [PubMed] [Europe PMC] [Abstract]
  9. "A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2."J. Virol. 83:7252-7260(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Immune signaling by RIG-I-like receptors."Immunity 34:680-692(2011) [PubMed] [Europe PMC] [Abstract]
  11. "RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium."J. Immunol. 186:1618-1626(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Ambivalent role of the innate immune response in rabies virus pathogenesis."J. Virol. 85:6657-6668(2011) [PubMed] [Europe PMC] [Abstract]
  13. "DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling."Mol. Cell. Biol. 31:3802-3819(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Regulation of RLR-mediated innate immune signaling--it is all about keeping the balance."Eur. J. Cell Biol. 91:36-47(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Sensing of viral nucleic acids by RIG-I: from translocation to translation."Eur. J. Cell Biol. 91:78-85(2012) [PubMed] [Europe PMC] [Abstract]
  16. "A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses."FEBS Lett. 587:2137-2142(2013) [PubMed] [Europe PMC] [Abstract]
  17. "The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA."J. Biol. Chem. 284:13881-13891(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors."J. Biol. Chem. 284:17465-17474(2009) [PubMed] [Europe PMC] [Abstract]
  19. "The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA."Nucleic Acids Res. 37:2014-2025(2009) [PubMed] [Europe PMC] [Abstract]