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Immunity Related GTPase Family, M (IRGM)

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IRGM1; LRG47; IFI1; Interferon-inducible protein 1; LPS-stimulated RAW 264.7 macrophage protein 47 homolog

Immunity Related GTPase Family, M (IRGM)
CCC M864
HGNC 29597
MGI 107567
PubMed 23335927
UniProt A1A4Y4
Wiki IRGM
Members of the p47 immunity-related GTPase (IRG) family, including IRGM, play an important role in the murine immune system; however, in humans this resistance system is greatly reduced. There is evidence that human IRGM plays a role in autophagy and control of intracellular mycobacteria .
In mouse, Irgm belongs to a family of gamma-interferon (IFNG)-induced GTP-binding proteins of approximately 47 to 48 kD. Murine Irgm1 induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. They also identified a function for human IRGM in the control of intracellular pathogens and reported that human IRGM plays a role in autophagy and in the reduction of intracellular bacillary load.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Immunity Related GTPase Family, M (IRGM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Immunity Related GTPase Family, M (IRGM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Immunity Related GTPase Family, M (IRGM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Immunity Related GTPase Family, M (IRGM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunity Related GTPase Family, M (IRGM) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Immunity Related GTPase Family, M (IRGM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Immunity Related GTPase Family, M (IRGM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Immunity Related GTPase Family, M (IRGM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Immunity Related GTPase Family, M (IRGM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunity Related GTPase Family, M (IRGM) ELISA Kit Customized Service Offer
  1. "Death and resurrection of the human IRGM gene."PLoS Genet. 5:E1000403-E1000403(2009) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage."Genome Biol. 6:R92.1-R92.18(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Human IRGM induces autophagy to eliminate intracellular mycobacteria."Science 313:1438-1441(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility." Nat. Genet. 39:830-832(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort."Am. J. Gastroenterol. 104:630-638(2009) [PubMed] [Europe PMC] [Abstract]
  7. "A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease."Nat. Genet. 43:242-245(2011) [PubMed] [Europe PMC] [Abstract]