EIG121 was upregulated 2- to 3-fold in postmenopausal endometrium in response to estrogen replacement. The predicted 1,013-amino acid EIG121 protein is 90% identical with the mouse ortholog, and related sequences are seen in fish, Xenopus, chicken, and C. elegans.
The level of EIG121 was an average of 3.8-fold higher in endometrial hyperplasias and 21-fold higher in grade 1 tumors. Expression was 3.5-fold higher in grade 3 endometrioid carcinoma than in benign endometrium and tended to decline with increasing tumor grade and disease stage. Immunohistochemical staining with an antibody to EIG121 showed faint staining of normal endometrial epithelium and intense staining of endometrioid tumors.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Estrogen Induced Gene 121 (EIG121) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Estrogen Induced Gene 121 (EIG121) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Estrogen Induced Gene 121 (EIG121) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Estrogen Induced Gene 121 (EIG121) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Estrogen Induced Gene 121 (EIG121) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Estrogen Induced Gene 121 (EIG121) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Estrogen Induced Gene 121 (EIG121) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Estrogen Induced Gene 121 (EIG121) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Estrogen Induced Gene 121 (EIG121) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Estrogen Induced Gene 121 (EIG121) | ELISA Kit Customized Service Offer |
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
- "Identification of a novel estrogen-regulated gene, EIG121, induced by hormone replacement therapy and differentially expressed in type I and type II endometrial cancer."Clin. Cancer Res. 11:8258-8264(2005) [PubMed] [Europe PMC] [Abstract]
- "The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress."Cell Death Dis. 1:E32-E32(2010) [PubMed] [Europe PMC] [Abstract]
- "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]