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MUS81 Endonuclease Homolog (MUS81)

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Crossover junction endonuclease MUS81

MUS81 Endonuclease Homolog (MUS81)
CCC M882
HGNC 29814
MGI 1918961
PubMed 24170812
RGD 1311957
UniProt Q96NY9
Wiki MUS81
MUS81 has associated endonuclease activity against structure-specific oligonucleotide substrates, including synthetic Holliday junctions. MUS81-associated endonuclease resolved Holliday junctions into linear duplexes by cutting across the junction exclusively on strands of like polarity. In addition, MUS81 protein abundance increased in cells following exposure to agents that block DNA replication. Taken together, these findings suggested a role for MUS81 in resolving Holliday junctions that arise when DNA replication is blocked by damage or by nucleotide depletion. The authors stated that MUS81 is not related by sequence to previously characterized Holliday junction-resolving enzymes, and it has distinct enzymatic properties that suggest it uses a novel enzymatic strategy to cleave Holliday junctions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MUS81 Endonuclease Homolog (MUS81) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MUS81 Endonuclease Homolog (MUS81) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MUS81 Endonuclease Homolog (MUS81) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MUS81 Endonuclease Homolog (MUS81) CLIA Kit Customized Service Offer
n/a ELISA Kit for MUS81 Endonuclease Homolog (MUS81) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MUS81 Endonuclease Homolog (MUS81) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MUS81 Endonuclease Homolog (MUS81) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MUS81 Endonuclease Homolog (MUS81) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MUS81 Endonuclease Homolog (MUS81) CLIA Kit Customized Service Offer
n/a ELISA Kit for MUS81 Endonuclease Homolog (MUS81) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MUS81 Endonuclease Homolog (MUS81) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MUS81 Endonuclease Homolog (MUS81) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MUS81 Endonuclease Homolog (MUS81) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MUS81 Endonuclease Homolog (MUS81) CLIA Kit Customized Service Offer
n/a ELISA Kit for MUS81 Endonuclease Homolog (MUS81) ELISA Kit Customized Service Offer
  1. "Human Mus81-associated endonuclease cleaves Holliday junctions in vitro."Mol. Cell 8:1117-1127(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities."EMBO J. 21:5577-5585(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and characterization of human MUS81-MMS4 structure-specific endonuclease."J. Biol. Chem. 278:21715-21720(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Identification and characterization of the human mus81-eme1 endonuclease."J. Biol. Chem. 278:25172-25178(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Mus81 endonuclease localizes to nucleoli and to regions of DNA damage in human S-phase cells."Mol. Biol. Cell 14:4826-4834(2003) [PubMed] [Europe PMC] [Abstract]
  8. "RNA interference inhibition of Mus81 reduces mitotic recombination in human cells."Mol. Biol. Cell 15:552-562(2004) [PubMed] [Europe PMC] [Abstract]
  9. "BLM helicase facilitates Mus81 endonuclease activity in human cells."Cancer Res. 65:2526-2531(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM."Mol. Cell 25:331-343(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links."Oncogene 27:5045-5056(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair."Mol. Cell 35:116-127(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair."Cell 138:63-77(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases."Cell 138:78-89(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]