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Neuroendocrine Differentiation Factor (NEDF)

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CHMP3; VPS24; Chromatin-modifying protein 3; Charged Multivesicular Body Protein 3; Vacuolar protein sorting-associated protein 24

Neuroendocrine Differentiation Factor (NEDF)
CCC M886
HGNC 29865
MGI 1913950
PubMed 11549700
RGD 708556
UniProt Q9Y3E7
Wiki VPS24
VPS24 is a component of ESCRT-III (endosomal sorting complex required for transport III) and is involved in multivesicular body biogenesis . The deduced 223-amino acid protein contains a putative nuclear localization signal near its N terminus. Northern blot analysis detected variable expression of 1.1-, 3.4-, and 8.5-kb VPS24 transcripts in all tissues examined. RT-PCR, but not Northern blot analysis, detected VPS24 in human prostate and mammary cell lines. Western blot analysis showed VPS24 as a doublet of about 29 and 31 kD. Immunofluorescence microscopy localized VPS24 in a punctate nuclear distribution.The deduced protein contains a basic N-terminal half and an acidic C-terminal half, and both halves contain coiled-coil regions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neuroendocrine Differentiation Factor (NEDF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neuroendocrine Differentiation Factor (NEDF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neuroendocrine Differentiation Factor (NEDF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neuroendocrine Differentiation Factor (NEDF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neuroendocrine Differentiation Factor (NEDF) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neuroendocrine Differentiation Factor (NEDF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neuroendocrine Differentiation Factor (NEDF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neuroendocrine Differentiation Factor (NEDF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neuroendocrine Differentiation Factor (NEDF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neuroendocrine Differentiation Factor (NEDF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neuroendocrine Differentiation Factor (NEDF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neuroendocrine Differentiation Factor (NEDF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neuroendocrine Differentiation Factor (NEDF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neuroendocrine Differentiation Factor (NEDF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neuroendocrine Differentiation Factor (NEDF) ELISA Kit Customized Service Offer
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  11. ErratumProc. Natl. Acad. Sci. U.S.A. 100:152845-152845(2003)
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  15. "Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation."J. Biol. Chem. 282:9805-9812(2007) [PubMed] [Europe PMC] [Abstract]
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  18. "Helical structures of ESCRT-III are disassembled by VPS4."Science 321:1354-1357(2008) [PubMed] [Europe PMC] [Abstract]
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  21. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
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