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Keratin 74 (KRT74)

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K6IRS4; KRT5C; KRT6IRS4; KB37; CK-74; Cytokeratin-74; Type II inner root sheath-specific keratin-K6irs4; Type-II keratin Kb37; Keratin, type II cytoskeletal 74

Keratin 74 (KRT74)
CCC M916
HGNC 28929
MGI 3629975
PubMed 21188418
UniProt Q7RTS7
Wiki KRT74
KRT74 belongs to the family of type II keratins that are specifically expressed in the inner root sheath of hair follicles. The deduced 529-amino acid protein has a calculated molecular mass of 57.9 kD. K6IRS4 shares a highly conserved rod domain and flanking non-alpha-helical H1 and H2 subdomains with K6IRS1, K6IRS2 , and K6IRS3. The head and tail domains are less related. Western blot analysis detected expression in root sheath extracts, but not in foot sole extracts. In situ hybridization and indirect immunofluorescence showed expression of K6IRS4 restricted to the Huxley layer of the inner root sheath. K6IRS4 was expressed in specialized Huxley cells, termed 'Flugelzellen,' which means 'winged cells,' along the area of differentiated Henle cells. K6IRS4 staining of the foot processes of Flugelzellen overlapped staining for K6IRS1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Keratin 74 (KRT74) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Keratin 74 (KRT74) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Keratin 74 (KRT74) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Keratin 74 (KRT74) CLIA Kit Customized Service Offer
n/a ELISA Kit for Keratin 74 (KRT74) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Keratin 74 (KRT74) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Keratin 74 (KRT74) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Keratin 74 (KRT74) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Keratin 74 (KRT74) CLIA Kit Customized Service Offer
n/a ELISA Kit for Keratin 74 (KRT74) ELISA Kit Customized Service Offer
  1. "K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle."J. Invest. Dermatol. 120:512-522(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18."J. Cell Sci. 114:2569-2575(2001) [PubMed] [Europe PMC] [Abstract]
  4. "K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle."J. Invest. Dermatol. 126:2377-2386(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Autosomal-dominant woolly hair resulting from disruption of keratin 74 (KRT74), a potential determinant of human hair texture."Am. J. Hum. Genet. 86:632-638(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Novel mutations in the keratin-74 (KRT74) gene underlie autosomal dominant woolly hair/hypotrichosis in Pakistani families."Hum. Genet. 129:419-424(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Autosomal recessive transmission of a rare KRT74 variant causes hair and nail ectodermal dysplasia: allelism with dominant woolly hair/hypotrichosis."PLoS ONE 9:E93607-E93607(2014) [PubMed] [Europe PMC] [Abstract]