Zinc Finger Protein 667 (ZNF667)

Mipu1 repressed expression of a reporter gene containing a promoter with the Mipu1-binding site in a dose-dependent manner. Mutation analysis showed that, unlike other zinc finger proteins, Mipu1 did not need its C-terminal zinc finger domain for nuclear targeting.

Jiang et al. (2007) characterized rat Znf667, which they called Mipu1, a gene identified based on its upregulation during myocardial ischemia/reperfusion. The predicted 608-amino acid rat Mipu1 protein contains an N-terminal Kruppel-associated box (KRAB) domain and 14 C-terminal C2H2 zinc finger motifs. Jiang et al. (2007) stated that Mipu1 is expressed mainly in brain and heart. Fluorescence microscopy showed nuclear localization of Mipu1 in transfected mouse myoblasts.